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Lesinurad
go.drugbank.com/drugs/DB11560ApprovedWithdrawnLesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptak...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersInsulin tregopil
go.drugbank.com/drugs/DB11568InvestigationalCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersRupatadine
go.drugbank.com/drugs/DB11614ApprovedInvestigationalRupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria. It was approved for marketing ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesTucatinib
go.drugbank.com/drugs/DB11652ApprovedInvestigationalTucatinib is a kinase inhibitor drug used with trastuzumab and capecitabine in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tuca...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsBryostatin 1
go.drugbank.com/drugs/DB11752InvestigationalBryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsAZD-1305
go.drugbank.com/drugs/DB11766InvestigationalAZD1305 has been used in trials studying the treatment and basic science of Atrial Flutter, Atrial Fibrillation, and Left Ventricle Function.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigationalSarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sariluma...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersArtefenomel
go.drugbank.com/drugs/DB11809InvestigationalArtefenomel has been investigated for the treatment of Malaria.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsBaricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigationalBaricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthrit...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesPritelivir
go.drugbank.com/drugs/DB11844InvestigationalPritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.
Categories: P-glycoprotein substrates