Search

Displaying results 121 - 130 of 134502 in total
  1. Pathway

    Torasemide Action Pathway (New)

    smpdb.ca/view/SMP0124537
    Drug action

    Torasemide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Torasemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Finerenone Action Pathway

    smpdb.ca/view/SMP0126009
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … Aldosterone is a mineralocorticoid hormone responsible for contributing to the regulation of blood pressure, sodium reabsorption, and potassium excretion and therefore, plays a role in blood pressure via

    Drugs: Potassium cation · Urea · Finerenone
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Triamterene Action Pathway (New)

    smpdb.ca/view/SMP0126281
    Drug action

    sodium uptake and potassium secretion. … This reduces the driving force for potassium movement into the tubular lumen and thus decreases potassium excretion.

    Drugs: Triamterene · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Rabeprazole Metabolism Pathway

    smpdb.ca/view/SMP0000616
    Drug metabolism

    The potassium transporting ATPase also converts water and ATP to a phosphate molecule and ADP. Alongside the transporters, potassium is brought into the cell. … The pathway begins in the parietal cell in the stomach, where rabeprazole and a hydrogen ion use the active metabolite in rabeprazole —rabeprazole thioether — to inhibit potassium-transporting ATPase at

    Drugs: Rabeprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  5. Pathway

    Eplerenone Action Pathway

    smpdb.ca/view/SMP0122731
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Eplerenone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Spironolactone Action Pathway (New)

    smpdb.ca/view/SMP0126006
    Drug action

    water (H2O) excretion and potassium (K+) retention. … In the principal cells of the distal convoluted tubule, sodium and water reabsorption occur, along with potassium excretion.

    Drugs: Spironolactone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Bumetanide Diruretic Action Pathway

    smpdb.ca/view/SMP0124517
    Drug action

    Bumetanide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Bumetanide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Quinethazone Action Pathway

    smpdb.ca/view/SMP0123030
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Quinethazone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Indapamide Diuretic Action Pathway

    smpdb.ca/view/SMP0123031
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Indapamide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Esomeprazole Metabolism Pathway (Old)

    smpdb.ca/view/SMP0000612
    Drug metabolism

    This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … In this pathway, esomeprazole is taken orally and is oxidized in the stomach to form the active metabolite of esomeprazole.

    Drugs: Esomeprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta