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Displaying results 121 - 130 of 134474 in total
  1. Pathway

    Moroctocog Alfa Action Pathway

    smpdb.ca/view/SMP0126849
    Drug action

    It acts by replacing coagulation factor VIII which is deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade. … Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII similar to the endogenous coagulation factor VIII.

    Drugs: Calcium · Moroctocog alfa
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  2. Pathway

    Bovine Thrombin Action Pathway

    smpdb.ca/view/SMP0126864
    Drug action

    Bovine thrombin is a coagulation factor also known under the brand name Thrombin-jmi, used to prevent bleeding during surgery. … It is administered as a topical and then cleared via thrombin inhibitor complexes and or through internalization and degradation by the endothelium.

    Drugs: Calcium · Thrombin
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  3. Pathway

    Plasminogen

    smpdb.ca/view/SMP0130469
    Physiological

    plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). … Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasminogen contains only a single

    Drugs: Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  4. Pathway

    Tranexamic Acid Action Pathway (New)

    smpdb.ca/view/SMP0124487
    Drug action

    In the presence of calcium, the active site transitions and a TF-VIIa complex is formed. This complex aids in activation of factors IX and X. … The pathway starts with plasma kallikrein activating factor XII. The activated factor XIIa activates factor XI. Factor IX is then activated by factor XIa.

    Drugs: Tranexamic acid · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  5. Pathway

    Aprotinin Kallikrein Antifibrinolytic Action Pathway

    smpdb.ca/view/SMP0126446
    Drug action

    The drug is slowly metabolized by lysosomal enzymes and is eliminated through the urine over 48 hours. … It slows the breakdown of fibrin clots to reduce bleeding by inhibiting the proteins plasminogen and kallikrein.

    Drugs: Calcium · Aprotinin
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  6. Pathway

    Fondaparinux Action Pathway

    smpdb.ca/view/SMP0126442
    Drug action

    It is further potentiated as fondaparinux activates antithrombin III that also inhibits coagulation factor X. … Avoiding herbs and supplements with anticoagulant and antiplatelet activity such as garlic, ginger, ginseng and ginkgo.

    Drugs: Fondaparinux · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  7. Pathway

    Protein C Action Pathway

    smpdb.ca/view/SMP0126878
    Drug action

    Activated Protein C acts as a serine protease that acts by inactivating coagulation factors V and VIII, decreasing clot formation. … Protein C is also known under brand names such as Balfaxar, Beriplex, Ceprotin, Kcentra and Octaplex used to treat purpura fulminans and or coumarin-induced skin necrosis.

    Drugs: Calcium · Protein C
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  8. Pathway

    Tenecteplase Action Pathway

    smpdb.ca/view/SMP0000283
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Tenecteplase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  9. Pathway

    Warfarin Action Pathway

    smpdb.ca/view/SMP0000268
    Drug action

    The enzyme vitamin K-dependent gamma carboxylase catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Warfarin · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  10. Pathway

    Argatroban.

    smpdb.ca/view/SMP0000276
    Drug action

    Argatroban does not effect serine proteases like, trypsin, factor Xa, plasmin, and kallikrein. … Direct thrombin inhibitors bind plasma and fibrin bound thrombin independently of co-factor antithrombin.The inhibition of thrombin reduces the stability of the clot and promotes clot break down.

    Drugs: Argatroban · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII