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Displaying results 121 - 130 of 134502 in total
  1. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    This promotes the loss of sodium and water from the body, but without depleting potassium. … Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure.It is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Eplerenone Action Pathway

    smpdb.ca/view/SMP0122731
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Eplerenone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Spironolactone Action Pathway (New)

    smpdb.ca/view/SMP0126006
    Drug action

    This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and … In the principal cells of the distal convoluted tubule, sodium and water reabsorption occur, along with potassium excretion.

    Drugs: Spironolactone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Lactose Degradation

    smpdb.ca/view/SMP0000457
    Metabolic

    GLUT1 actively transports glucose and galactose with 2 sodium ions. … A sodium/potassium ATPase makes ATP by moving three sodium ions to the blood per two potassium ions that cross into the epithelial cell, giving the GLUT1 transporter energy to work.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0000458
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Trehalose Degradation

    smpdb.ca/view/SMP0000467
    Metabolic

    These are then transported into the epithelial cells along with a sodium ion by a sodium/glucose cotransporter, which can bring glucose up its gradient along with sodium moving down its gradient. … It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and dehydration.

    Drugs: ATP · Potassium cation
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0125808
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Kidney Function - Collecting Duct

    smpdb.ca/view/SMP0121011
    Physiological

    In addition, sodium and potassium are also reabsorbed back into the systemic circulation at the collecting duct via potassium and sodium channels. … As a result, a high concentration of sodium and potassium in the blood vessels occurs. Some urea and other ions may be reabsorbed as well.

    Drugs: Potassium cation · Zinc · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Torasemide Action Pathway (New)

    smpdb.ca/view/SMP0124537
    Drug action

    Torasemide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Torasemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Ethacrynic Acid Diuretic Action Pathway

    smpdb.ca/view/SMP0124515
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Etacrynic acid · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1