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Lincomycin
go.drugbank.com/drugs/DB01627ApprovedInvestigationalVet approved[A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains
Zolbetuximab
go.drugbank.com/drugs/DB15118ApprovedInvestigationalZolbetuximab (previously claudiximab) is a chimeric cytolytic antibody comprising variable regions derived from mouse anti-human claudin-18 isoform 2 monoclonal antibody and constant regions derived from human IgG1. It is specifically ta...
Sonidegib
go.drugbank.com/drugs/DB09143ApprovedInvestigationalSonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTeplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigational[L44091] Fc-receptors can bind to the "tail-end" anti-CD3 antibodies in an antigen-non-specific manner and lead to severe adverse effects related to cytokine release syndrome (CRS). … Teplizumab was designed as an Fc-non-binding antibody in order to reduce the incidence of CRS.
Alizapride
go.drugbank.com/drugs/DB01425InvestigationalAlizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, inclu...
Categories: Dopamine D2 Receptor AntagonistsPork collagen
go.drugbank.com/drugs/DB14100ApprovedIt serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods. … Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic
Mixtures: P3 Rg, P3 RgChlorphentermine
go.drugbank.com/drugs/DB01556ApprovedIllicitWithdrawnA sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension.
Synonyms: a,a-Dimethyl-p-chlorophenethylamineElvitegravir
go.drugbank.com/drugs/DB09101ApprovedInvestigationalAlthough available as a single dose tablet, elvitegravir must be used in combination with an HIV protease inhibitor coadministered with ritonavir and another antiretroviral drug.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InducersAlfentanil
go.drugbank.com/drugs/DB00802ApprovedIllicitInvestigationalAlfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. … It produces an early peak analgesic effect and fast recovery of consciousness.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates