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Displaying results 1321 - 1330 of 10000 in total
  1. Target

    Disintegrin and metalloproteinase domain-containing protein 9

    go.drugbank.com/bio_entities/BE0003412
    TargetHumans

    Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. … May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 9
  2. Target

    Sodium- and chloride-dependent GABA transporter 3

    go.drugbank.com/bio_entities/BE0004733
    TargetHumans

    Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447).

    Polypeptides: Sodium- and chloride-dependent GABA transporter 3
  3. Target

    Disintegrin and metalloproteinase domain-containing protein 33

    go.drugbank.com/bio_entities/BE0019245
    TargetHumans

    Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed … Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways (PubMed:33982767).

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 33
  4. Drug

    Natalizumab

    go.drugbank.com/drugs/DB00108
    ApprovedInvestigational

    [A261331] On August 24, 2023, the first biosimilar to natalizumab, natalizumab-sztn, was approved by the FDA.[L48041] Natalizumab was approved by the European Commission on September 22, 2023. … In 2006, the FDA reintroduced the drug to the market for multiple sclerosis.[A261326] Natalizumab was further approved by the FDA for the treatment of Crohn's Disease in January 2008.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: TYSABRI® SUBCUTÁNEO 150MG/ML
  5. Drug

    Canagliflozin

    go.drugbank.com/drugs/DB08907
    ApprovedInvestigational

    It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type … Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise

    Mixtures: Vokanamet (Canagliflozin 150mg/ Metformin 500mg) Film-Coated Tablet, Vokanamet (Canagliflozin 150mg/ Metformin 850mg) Film-Coated TabletCategories: Alimentary Tract and Metabolism, metformin and canagliflozin
  6. Drug

    Tizanidine

    go.drugbank.com/drugs/DB00697
    ApprovedInvestigational

    It may also be caused by musculoskeletal injury [A177583]. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. … Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons

    Mixtures: MYOS -NOR F TABLETASProducts: SIRDALUD 2MG, TIZANIDIN TEVA 2MG TABL
  7. Drug

    Dyphylline

    go.drugbank.com/drugs/DB00651
    ApprovedWithdrawn

    Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

    Mixtures: Dyphylline and GuaifenesinCategories: Xanthines and Adrenergics, diprophylline and adrenergics
  8. Drug

    (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide

    go.drugbank.com/drugs/DB08564
    Experimental

    Synonyms: (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
  9. Drug

    3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol

    go.drugbank.com/drugs/DB07079
    Experimental

    Synonyms: 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
  10. Drug

    Calcium Phosphate

    go.drugbank.com/drugs/DB11348
    ApprovedInvestigational

    Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] [L851].

    Mixtures: Multiple Vitamins and Minerals, Multiple Vitamins and MineralsCategories: Alimentary Tract and Metabolism, ascorbic acid (vit C) and calcium