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Ramucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalIn contrast to other agents directed against VEGFR-2, ramucirumab binds a specific epitope on the extracellular domain of VEGFR-2, thereby blocking all VEGF ligands from binding to it. … Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells.
Categories: Vascular Endothelial Growth Factor Receptor 2 AntagonistProducts: CYRAMZA 100MG/10 ML INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇEREN FLAKON, 2 ADET, CYRAMZA 500 MG/50 ML İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇEREN FLAKON, 1 ADETPlasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigationalThe composition of PPFh should be 5% of protein from which 83% should consist of albumin and no more of 17% should be globulin. … [L2262] The proteins in PPFh are stabilized with sodium caprylate and acetyltryptophan and it contains some electrolytes such as sodium, potassium and chloride.[L2261]
Mixtures: Varitect CP 25 I.E./ml InfusionslösungProducts: PLASMANATE - 5% ( 250 ML VIAL ), PLASMANATE - 5% (50 ML VIAL)Etidronic acid
go.drugbank.com/drugs/DB01077ApprovedInvestigational[A203111] Etidronic acid was granted FDA approval on 1 September 1977.[L13901] … Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid].
Synonyms: 1-Hydroxy-1,1-diphosphonoethane, (1-Hydroxyethylene)diphosphonic acidProducts: DIDRONAT 200 MG TABLET, 60 ADET, DIDRONAT 400 MG TABLET, 30 ADETVenetoclax
go.drugbank.com/drugs/DB11581ApprovedInvestigationalProteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process [A18565], [A18566]. … Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label].
Categories: BCL-2 Inhibitor, Heterocyclic Compounds, 2-RingSynonyms: 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide, 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamideSotalol
go.drugbank.com/drugs/DB00489ApprovedInvestigationalSotalol is a methanesulfonanilide developed in 1960.[A178579] It was the first of the class III anti arrhythmic drugs.[A178579] Sotalol was first approved as an oral tablet on 30 October 1992. … in atrial fibrillation or flutter.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide, β-cardoneTerfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-olEdetate calcium disodium anhydrous
go.drugbank.com/drugs/DB14598ApprovedInvestigationalEdetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. … [L12774] It is on the World Health Organization Model List of Essential Medicines.[A204173] Edetate calcium disodium was granted FDA approval on 16 July 1953.[L12774]
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP3A InhibitorsProducts: Calcium Disodium Versenate Liq 200mg/ml, EDETATO CALCICO DISODICO 20%Ixazomib
go.drugbank.com/drugs/DB09570ApprovedInvestigational[A264319] It was later approved by Health Canada on August 3, 2016,[L51239] and by the EMA on November 21, 2016. … [A7948] More than 99% of the drug compound is the R-enantiomer.[A264329] Ixazomib was approved by the FDA on November 20, 2015, making it the first oral proteasome inhibitor approved in the US.
Synonyms: 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diacetic acid, BORONIC ACID, B-((1R)-1-((2-((2,5-DICHLOROBENZOYL)AMINO)ACETYL)AMINO)-3-METHYLBUTYL)-Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexFomepizole
go.drugbank.com/drugs/DB01213ApprovedVet approvedFomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. … Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
Synonyms: 4-methylpyrazol, 4-methylpyrazoleCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesEptinezumab
go.drugbank.com/drugs/DB14040ApprovedInvestigational[F94,A33105,A33106,A33108] It was approved by the FDA in February 2020 for the preventive treatment of migraine headaches in adults.[L12318] … Eptinezumab is a fully-humanized IgG1 antibody manufactured using yeast (_Pichia pastoris_) and developed by Lundbeck Seattle Biopharmaceuticals.
Products: Vyepti® 100 mg/mL concentrate for solution for infusion, VYEPTI CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/ML