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Displaying results 1371 - 1380 of 10000 in total
  1. Drug

    Vinflunine

    go.drugbank.com/drugs/DB11641
    ApprovedInvestigational

    Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. … Having an incidence of 429,700 new cases per year worldwide, urothelial carcinoma of the bladder is one of the most common malignancies that mostly affects individuals aged 50–79 years [A32626].

    Synonyms: 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine, 20',20'-difluoro-3',4'-dihydrovinorelbineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  2. Drug

    Tolperisone

    go.drugbank.com/drugs/DB06264
    Investigational

    Tolperisone is an oral, centrally acting muscle relaxant. Its precise mechanism is not completely understood, though it blocks sodium and calcium channels. It possesses a high affinity for nervous system tissue, reaching highest concentr...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: TOLPERISON-NEURAX 50 MG, TOLPERISON-NEURAX 150 MG
  3. Drug

    Aprepitant

    go.drugbank.com/drugs/DB00673
    ApprovedInvestigational

    Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).

    Mixtures: EMEND® 80 MG/125 MG, EMEND® 80 MG/125 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Inducers
  4. Drug

    Disperse Blue 106

    go.drugbank.com/drugs/DB14203
    Approved

    Disperse Blue 106 is used in allergenic testing.

    Synonyms: Disperse Blue 106, 5-Nitro-2-(2-methyl-4-(N-ethyl-N-(2-hydroxyethyl)amino)phenylazo)thiazole
  5. Drug

    Interferon gamma-1b

    go.drugbank.com/drugs/DB00033
    ApprovedInvestigational

    Human Interferon gamma-1b (140 residues), produced from E. coli. … The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: IMUKIN 100 Mikrogramm/0,5 ml Injektionslösung
  6. Drug

    Gadoteridol

    go.drugbank.com/drugs/DB00597
    ApprovedInvestigational

    [A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs) that was mandated by the EMA to replace linear gadolinium-based contrast agents due to concerns about retained

    Synonyms: gadolinium 2,2',2''-[10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetateProducts: ProHance 279.3 mg/ml solution for injection
  7. Drug

    Menotropins

    go.drugbank.com/drugs/DB00032
    ApprovedInvestigational

    It is used as a fertility medication that is injected either subcutaneously or intramuscularly.

    Products: MERİOFERT 150 IU ENJEKSİYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ, 10 FLAKON, MERİOFERT 75 IU ENJEKSİYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ, 10 FLAKON
  8. Drug

    Azilsartan medoxomil

    go.drugbank.com/drugs/DB08822
    ApprovedInvestigational

    enzyme (ACE) inhibitors that are also used as first-line treatment for hypertension. … As hypertension is a major risk factor for cardiovascular disease,[A7354] early management of hypertension has several implications on patients' survival rate and quality of life in the future.

    Mixtures: EDARBYCLOR (TABLETS) 40 MG/12.5 MG, EDARBYCLOR (TABLETS) 40 MG/12.5 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
  9. Drug

    Methyl salicylate

    go.drugbank.com/drugs/DB09543
    ApprovedInvestigationalVet approved

    It is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions. … The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments.

    Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, SADRÜD % 10 + % 15 JEL, 50 GProducts: Methyl Salicylate 10%, Oil Of Wintergreen 100%
  10. Drug

    Ethinylestradiol

    go.drugbank.com/drugs/DB00977
    ApprovedInvestigational

    Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability. … [A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]

    Mixtures: MIRANOVA 100 MCG/20 MCG KAPLI TABLET, 21 ADET, REGİNON 0.02 MG/0.075 MG DRAJE , 1050 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates