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Tacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalIt was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. … It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic IndexProducts: Qvaya 1 mg/ml Emulsion zur Anwendung auf der Haut, PROGRAF® XL CAPSULAS DE LIBERACIONPROLONGADA DE 1 MGAtropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedAtropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods.
Synonyms: dl-Hyoscyamine, dl-tropyltropateMixtures: LOMOTİL 2,5 MG + 0,025 MG / 5 ML ORAL ÇÖZELTİ, 60 ML, PHARMANIAGA DIPHENOXYLATE A TABLETPhylloquinone
go.drugbank.com/drugs/DB01022ApprovedInvestigationalVitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin. … [A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity
Mixtures: CALCIDOSE 1200 MG/800 IU/65 MCG EFERVESAN TABLET, 45 ADET, CALCIDOSE 600 MG/400 IU/32.5 MCG EFERVESAN TABLET, 30 ADETProducts: VITAMINA K1 10 MG/ML, KONAKION MM INJECTION 10 mg/mlDoxycycline
go.drugbank.com/drugs/DB00254ApprovedInvestigationalVet approvedDoxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline].[L42880] It is a second-generation tetracycline that was first discovered in 1967. … [A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.[A251730]
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsInternational brands: Nu-DoxycyclineIron polymaltose
go.drugbank.com/drugs/DB15763ApprovedInvestigationalWithdrawnMixtures: FERLOS 100 MG/0.35 MG TABLET, 30 ADET, FERRUM HAUSMANN FORT 100 MG/0,35 MG FİLM TABLET, 30 ADETProducts: SANTAFER 50MG/5ML ŞURUP, 150 ML, VEGAFERON 100 MG/5 ML ORAL ÇÖZELTİ, 10 ADETRocuronium
go.drugbank.com/drugs/DB00728ApprovedInvestigational[Sugammadex] is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium. … Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action.
Products: BROMURO DE ROCURONIO 50 MG/5ML., BROMURO DE ROCURONIO 50 MG /5MLDimenhydrinate
go.drugbank.com/drugs/DB00985ApprovedInvestigationalDimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950. … [L32995] Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery.
Mixtures: Arlevert 20 mg/40 mg TablettenInternational brands: Vomex ABaclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigationalBaclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.
Synonyms: DL-Baclofen, DL-4-Amino-3-p-chlorophenylbutanoic acidInternational brands: Nu-BaclofenFlecainide
go.drugbank.com/drugs/DB01195ApprovedInvestigationalWithdrawn[A186880] Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. … [A186931] It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexProducts: TAMBOCOR (TABLET 100 MG), Ag-flecainidePeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigationalPeginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … Peginterferon alfa-2b is available as a variable dose injectable product (tradename Pegintron) used for the treatment of chronic Hepatitis C.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP2C9 InducersProducts: PEG-INTRON CLEARCLICK FOR INJECTION 150 mcg/0.5 ml, PEGINTRON 150 MCG ENJEKSIYONLUK COZELTI TOZU VE COZUCUSU, 4 ADET