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Larotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … an important role in tumor cell growth and survival.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: VITRAKVI®CÁPSULAS DE 100MGDesipramine
go.drugbank.com/drugs/DB01151ApprovedThe antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. … In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsSynonyms: N-(3-methylaminopropyl)iminobibenzyl, 5-(γ-methylaminopropyl)iminodibenzylUblituximab
go.drugbank.com/drugs/DB11850ApprovedInvestigational[A244210] Ublituximab is a chimeric anti-CD20 IgG1κ antibody produced in the rat YB2/0 cell line to target a unique epitope and enhance ADCC compared to other approved anti-CD20 antibodies such as [rituximab … CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions.
Categories: Leukemia, Lymphocytic, Chronic, B-Cell, drug therapyAntigen peptide transporter 1
go.drugbank.com/bio_entities/BE0003109TransporterHumansIn complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25377891, PubMed:25656091
Synonyms: Peptide transporter involved in antigen processing 1Idelalisib
go.drugbank.com/drugs/DB09054ApprovedInvestigationalFor the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other … In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils
Categories: Class Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one, 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-oneMethyl salicylate
go.drugbank.com/drugs/DB09543ApprovedInvestigationalVet approvedIt is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions. … The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments.
Mixtures: Re-Lieved 3 in 1 Patch, NuDroxiPAK E-400Categories: Compounds used in a research, industrial, or household settingAlginic acid
go.drugbank.com/drugs/DB13518ApprovedInvestigationalWithdrawnAlginic acid is a linear polymer consisted of L-glucuronic acid and D-mannuronic acid residues connected via 1,4-glycosidic linkages [A32961]. … It is present in cell walls of brown algae where it forms a viscous gel when binding with water.
Synonyms: (Alginate)n+1, (Alginate)nMixtures: GAVISCON BRUCIORE E INDIGESTIONE, GAVISCON BRUCIORE E INDIGESTIONELifitegrast
go.drugbank.com/drugs/DB11611ApprovedInvestigationalIt is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. … The ophthalmic solution was approved in July, 2016 under the trade name Xiidra.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP2C9 InhibitorsSuprofen NSAID Action Pathway
smpdb.ca/view/SMP0124582Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … The overall result is a reduction in pain and inflammation in the eyes and the prevention of pupil constriction during surgery.
Enzymes: Prostaglandin E synthaseKetoprofen NSAID Action Pathway
smpdb.ca/view/SMP0124635Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because ketoprofen decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthase