Search
Pergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnIt was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. … Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease.
Categories: Heterocyclic Compounds with 4 or More Rings, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: PERGOLIDE EG, PERGOLID-NEURAX 1 MGZonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigational[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors … This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Categories: combinations of sulfonamides, Compounds used in a research, industrial, or household settingProducts: ZONISAHEXAL 25 MG HKP, ZONISAHEXAL 50 MG HKPInotuzumab ozogamicin
go.drugbank.com/drugs/DB05889ApprovedInvestigational[A20352] Inotuzumab ozogamicin was first approved by the European Commission in June 2017 for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). … [A20352] The antibody portion of the drug binds to CD22 receptors expressed on leukemic B cells and intracellularly releases N-acetyl-gamma-calicheamicin dimethylhydrazide, which produces cytotoxic effects
Categories: CD22 (Clusters of Differentiation 22) inhibitorsProducts: BESPONSA 1 MG IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ, 1 ADETIsatuximab
go.drugbank.com/drugs/DB14811ApprovedInvestigationalgranted Orphan Drug designation and approved on March 2nd, 2020, for the treatment of multiple myeloma. … [L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some immune cells that is highly expressed by malignant plasma cells in multiple myeloma.
Categories: CD38 (Clusters of Differentiation 38) inhibitorsProducts: SARCLİSA 100 MG/5 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, SARCLİSA 500 MG/25 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETAcrivastine
go.drugbank.com/drugs/DB09488ApprovedAcrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. … As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension
Mixtures: DUACT 8 MG/60 MG KAPSÜL, 30 ADETEletriptan
go.drugbank.com/drugs/DB00216ApprovedInvestigationalEletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: ELETRIPTAN EG, RELPAX TABLET 80 mgEverolimus
go.drugbank.com/drugs/DB01590ApprovedInvestigationalEverolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. … In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Synonyms: 40-O-(2-hydroxyethyl)-rapamycin, 42-O-(2-Hydroxyethyl)rapamycinCategories: Mammalian target of rapamycin (mTOR) kinase inhibitorsAmbroxol
go.drugbank.com/drugs/DB06742ApprovedInvestigationalAmbroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. … It stimulates synthesis and release of surfactant by type II pneumocytes.
Mixtures: SERBOL-G, VAKSAN COMPOSITUM JARABE ADULTOS 15 MG/0.01 MG/ 5MLProducts: AMBROXOLO EG, BOOTS AMBROXOL 30 MGSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnor longer to 12 or 24 weeks [A19630] depending on prior response status and presence of HIV-1 co-infection. … or second-line threapies for treatment-naïve patients as adjunct to sofosbuvir treatment for genotype 1 or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4.
Categories: combinations of sulfonamides, Antivirals for treatment of HCV infectionsProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADETRibavirin
go.drugbank.com/drugs/DB00811ApprovedInvestigationalCombination therapy of ribavirin and [DB00008] results in the SVR of 44% in patients with genotype 1 infection and 70% in patients with genotype 2-6. … Newer drugs developed as Hepatitis C viral infection treatments can be used to reduce or eliminate the use of ribavirin, which are associated with serious adverse effects.
Categories: Antivirals for treatment of HCV infectionsProducts: MODERIBA® 200 MG, COPEGUS TABLET 200 mg