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Entrectinib
go.drugbank.com/drugs/DB11986ApprovedInvestigational[L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval based on early trial data. … This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929]
Synonyms: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexCytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalCytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. … A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone, 1-beta-D-ArabinofuranosylcytosineDavesomeran
go.drugbank.com/drugs/DB17091ApprovedInvestigationalSimilar to the previous Moderna COVID-19 vaccine, Moderna Bivalent vaccine encodes the full-length pre-fusion stabilized spike (S) protein to elicit an immune response. … Davesomeran is a mRNA vaccine used in conjunction with [elasomeran] as part of the Moderna Bivalent COVID-19 vaccine.
Mixtures: Spikevax Bivalent (original / Omicron Ba.4/5)Homosalate
go.drugbank.com/drugs/DB11064ApprovedHomosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. … It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate.
Synonyms: 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoateMixtures: Miami Beach SPF 50 Kids C/S Sunscreen, Miami Beach SPF 50 Kids C/S SunscreenREP8839
go.drugbank.com/drugs/DB05224ExperimentalREP8839 is a novel methionyl-tRNA synthetase (MetS) inhibitor being developed by Replidyne (GlaxoSmithKline licensed REP8839 to Replidyne in June of 2003).
Categories: Heterocyclic Compounds, 1-RingFamtozinameran
go.drugbank.com/drugs/DB17088ApprovedInvestigational[L43917] Famtozinameran is an mRNA vaccine encoding the S glycoprotein of SARS-CoV-2 Omicron variant lineages BA.4 and BA.5. … The Omicron variant of SARS-CoV-2 is a variant of concern that was first reported in November 2021.
Mixtures: Comirnaty Original & Omicron Ba.4/ba.5, Comirnaty Original & Omicron Ba.4/ba.5Epcoritamab
go.drugbank.com/drugs/DB16672ApprovedInvestigationalContinued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). … B cells.
Categories: Bispecific CD20-directed CD3 T Cell EngagerProducts: Tepkinly 4 mg/0,8 ml Enjeksiyonluk Çözelti (1 adet), Tepkinly 48 mg Enjeksiyonluk Çözelti (1 adet)Elasomeran
go.drugbank.com/drugs/DB15654ApprovedInvestigationalThe Moderna COVID-19 Vaccine (mRNA-1273; Elasomeran) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe … acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Synonyms: MRNA-1273 SARS-COV-2Mixtures: Spikevax Bivalent (original / Omicron Ba.4/5)Dabrafenib
go.drugbank.com/drugs/DB08912ApprovedInvestigationalDabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexProducts: TAFINLAR®75 MG CÁPSULAS DURAS, TAFINLAR® 50 MG CÁPSULAS DURASFerrous fumarate
go.drugbank.com/drugs/DB14491ApprovedInvestigationalUsed in treatment of iron deficiency anemia.
Synonyms: Iron(2+) fumarateMixtures: WOMEN`S MULTIVITE WITH EVENING PRIMROSE OIL,ROYAL JELLY & KOREAN GINSENG, Se-Vate 21/7