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Displaying results 1431 - 1440 of 10000 in total
  1. Drug

    Glycine

    go.drugbank.com/drugs/DB00145
    ApprovedInvestigationalNutraceuticalVet approved

    It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

    Mixtures: Aminosyn II and Dextrose, Aminosyn II and DextroseCategories: Blood and Blood Forming Organs, Amino Acids, Peptides, and Proteins
  2. Drug

    Belimumab

    go.drugbank.com/drugs/DB08879
    ApprovedInvestigational

    [A251495, L42705] By binding to BLyS and blocking its interaction with B cell receptors, belimumab inhibits the survival of B cells. … [A251520] It is currently used to treat SLE and lupus nephritis.[L42630]

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Benlysta Powder for Solution for Infusion 120mg
  3. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 4

    go.drugbank.com/bio_entities/BE0004687
    EnzymeTargetHumans

    Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). … May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4
  4. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 13

    go.drugbank.com/bio_entities/BE0009336
    EnzymeTargetHumans

    Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13
  5. Target

    T-cell immunoreceptor with Ig and ITIM domains

    go.drugbank.com/bio_entities/BE0010742
    TargetHumans

    In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). … In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116).

    Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
  6. Drug

    Etravirine

    go.drugbank.com/drugs/DB06414
    ApprovedInvestigational

    On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral … Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase

    Products: INTELENCE TABLET 100MG
  7. Drug

    Epinephrine

    go.drugbank.com/drugs/DB00668
    ApprovedInvestigationalVet approved

    Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. … other allergens, and to prolong the action of infiltration anesthetics [F2136].

    Mixtures: Ana-kit (2mg/tab Orl, 1mg/ml Liq Sc Im), LIDOFAST 40MG/2ML+0,025MG/2ML ENJEKSIYONLUK COZELTI ICEREN AMPUL, 20 ADETCategories: Epinephrine and similars, Adrenergic and Dopaminergic Agents
  8. Drug

    Activated charcoal

    go.drugbank.com/drugs/DB09278
    ApprovedInvestigational

    Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. … It is used as a gastric decontaminant and emergency medication to treat poisonings following excessive oral ingestion of certain medications or poisons by absorbing most drugs and toxins.

    Categories: Antacids and Adsorbents, Alimentary Tract and MetabolismProducts: Deltacarbon Tablet 250mg, ULTRACARBON TABLETS 250MG
  9. Drug

    Chlorprothixene

    go.drugbank.com/drugs/DB01239
    ApprovedInvestigationalWithdrawn

    Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

    Products: CHLORPROTHIXEN-NEURAX 15MG, CHLORPROTHIXEN-NEURAX 50MG
  10. Drug

    Carbamoylcholine

    go.drugbank.com/drugs/DB00411
    Approved

    [A226315] Carbamoylcholine was initially used as a treatment for migraines,[A226365] induction of diuresis,[A226370] and other parasympathetic effects.

    Categories: Antiglaucoma Preparations and MioticsProducts: Carbachol Tab 2mg