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Kappadione
go.drugbank.com/drugs/DB09332ApprovedStudies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study of mice [L1544]. … It has been found to have carcinogenic potential in mammalian cells as well as cytotoxic properties [L1544].
Aducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalthe data [A235720] and aducanumab was granted accelerated FDA approval on 7 June 2021. … [A235668] Based on Mini-Mental State Examination and Clinical Dementia Rating (CDR), patients taking aducanumab showed signs of slowing progression; however, these data were controversial.
Dexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawn[PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. … It appears to inhibit formation of a toxic iron-anthracycline complex.
Categories: Compounds used in a research, industrial, or household settingBrilliant green cation
go.drugbank.com/drugs/DB11279ApprovedVet approvedBrilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. … Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.
Synonyms: Brilliant green ionCategories: Compounds used in a research, industrial, or household settingEmtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigational[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019] … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection
Mixtures: INMUNOVIR DUO, EMTRICITABINA E TENOFOVIR DISOPROXIL DR. REDDY'SCategories: Antivirals used in combination for the treatment of HIV infectionsSulfathiazole
go.drugbank.com/drugs/DB06147ApprovedVet approvedWithdrawnExcept for those formulated for vaginal use, the FDA withdrew its approval for the use of all drug products containing sulfathiazole.[L43942] … It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
Mixtures: STREPTOSIL CON NEOMICINA, STREPTOSIL CON NEOMICINACategories: combinations of sulfonamidesFoscarnet
go.drugbank.com/drugs/DB00529ApprovedInvestigationalAn antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Zanubrutinib
go.drugbank.com/drugs/DB15035ApprovedInvestigationalZanubrutinib was granted accelerated approval by the FDA in November 2019 based on clinical trial results that demonstrated an 84% overall response rate from zanubrutinib therapy in patients with MCL,[ … L10166] which measures the proportion of patients in a trial whose tumour is entirely or partially destroyed by a drug.
Dimercaprol
go.drugbank.com/drugs/DB06782ApprovedIn addition, it has in the past been used for the treatment of Wilson's disease, a genetic disorder in which the body tends to retain copper. … Dimercaprol has toxic potential, and its use may be followed by a variety of adverse effects.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 2,3-mercaptopropan-1-olPegulicianine
go.drugbank.com/drugs/DB18731ApprovedInvestigationalIt is used following surgical resection of the primary tumor to detect areas of remaining cancer. … Pegulicianine itself is a prodrug comprising three main fragments, one of which contains a fluorescence quencher that keeps the parent molecule optically inactive.
Categories: Compounds used in a research, industrial, or household setting