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Clofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawn[A203144] Although it carries _in vitro_ activity against other mycobacterium, such as _Mycobacterium tuberculosis_, it is generally considered an ineffective treatment in comparison to classic tuberculosis
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesArachidonic Acid
go.drugbank.com/drugs/DB04557ApprovedInvestigationalWithdrawnAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides.
Mixtures: NEUROGAIN PB VEGICAP CAPSULE 500MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesCladribine
go.drugbank.com/drugs/DB00242ApprovedInvestigationalCladribine is a purine analogue or a chlorinated derivative of adenine that causes apoptosis of B and T lymphocytes. Cladribine was first approved in the United States in 1993 initially as a treatment for a number of hematological malign...
Synonyms: 2-chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purineCategories: P-glycoprotein substratesZimlovisertib
go.drugbank.com/drugs/DB15143InvestigationalPF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects).
Methionine
go.drugbank.com/drugs/DB00134ApprovedInvestigationalNutraceuticalA sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Mixtures: SOLUCION DP-AMINE, Aminosyn-PFFenofibrate
go.drugbank.com/drugs/DB01039ApprovedInvestigationalFenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia. Fenofibrate was granted FDA approval on 31 December 1993.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionateEsketamine
go.drugbank.com/drugs/DB11823ApprovedInvestigational[L5593] Esketamine may prove to be a promising treatment for patients diagnosed with major depressive disorder who have not experienced an improvement in symptoms despite treatment with various medications
Categories: Non-Competitive N-Methyl D-Aspartate (NMDA) Receptor Antagonists, Cytochrome P-450 SubstratesAmitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in...
Mixtures: Sentravil PM-25, Limbitrol DSCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPF-06821497
go.drugbank.com/drugs/DB14799InvestigationalPF-06821497 is under investigation in clinical trial NCT03460977 (PF-06821497 Treatment Of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma).
PF-05089771
go.drugbank.com/drugs/DB14856InvestigationalPF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).