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Ponatinib
go.drugbank.com/drugs/DB08901ApprovedInvestigationalPonatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesProducts: Iclusig 30 mg Film Kaplı Tablet (30 adet), Iclusig 15 mg Film Kaplı Tablet (30 adet)Gefitinib
go.drugbank.com/drugs/DB00317ApprovedInvestigationalActing in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesProducts: GEFTRA® 250 MG, IRESSA TABLET 250 mgNitric Oxide
go.drugbank.com/drugs/DB00435ApprovedInvestigationalThis gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: Neophyr 1000 ppm mol/mol Gas zur medizinischen Anwendung, druckverdichtet, Noxivent 101Fluocinonide
go.drugbank.com/drugs/DB01047ApprovedInvestigationalA topical glucocorticoid used in the treatment of eczema.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: Fluocinonide Cream (Emulsified Base)Homosalate
go.drugbank.com/drugs/DB11064ApprovedHomosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. Salicylates prevent direct skin exposure to the sun’s harmful rays by...
Mixtures: Mango Bay SPF 50, Olay Professional ProX Age Repair SPF 30Products: Sun Protection Facial SPF 50, Facial Primer Protector SPF 50Typhoid Vi polysaccharide vaccine
go.drugbank.com/drugs/DB10803ApprovedInvestigationalTyphoid Vi polysaccharide vaccine is a vaccine that is administered intramuscularly. It is an active immunization for the prevention of typhoid fever caused by S typhi and is approved for use in persons two years of age or older. The vac...
Products: TYPHIM VI INJECTION 0.025 mg/0.5 ml, TYPHIM VI (20 DOSES)Rimonabant
go.drugbank.com/drugs/DB06155ApprovedWithdrawnIt was rejected for approval for use in the United States. … This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ACOMPLIA ® COMPRIMIDOS RECUBIERTOS20 MGSertindole
go.drugbank.com/drugs/DB06144ApprovedWithdrawnIt has once again been approved and should soon be available on the French and Australian market. … It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects.
Synonyms: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-oneCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsCabergoline
go.drugbank.com/drugs/DB00248ApprovedInvestigationalCabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Categories: Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT2 Receptor AgonistsProducts: CABASER 1 MG TABLET, 20 ADET, CABASER 2 MG TABLET, 20 ADETSorafenib
go.drugbank.com/drugs/DB00398ApprovedInvestigationalSorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approve...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: NEXAVAR TABLET 200 mg, Sorafenib TEVA 200 mg Filmtabletten