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Displaying results 141 - 150 of 134683 in total
  1. Pathway

    Bupranolol Action Pathway

    smpdb.ca/view/SMP0000670
    Drug action

    Bupranolol is a nonselective beta-blocker with structural similarity to propanolol. Both drugs do not have intrinsic sympathomimetic activity. It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibi...

    Drugs: ATP · Potassium cation · Calcium · Bupranolol
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  2. Pathway

    Atenolol Action Pathway

    smpdb.ca/view/SMP0000298
    Drug action

    Binding of atenolol inhibits the G protein signalling cascade and reduces heart rate, blood pressure, cardiac output and reflex orthostatic hypotension. … Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity.

    Drugs: ATP · Atenolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  3. Pathway

    Bisoprolol Action Pathway

    smpdb.ca/view/SMP0000300
    Drug action

    Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Bisoprolol (also known as Zebeta) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.

    Drugs: ATP · Bisoprolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  4. Pathway

    Metoprolol Action Pathway

    smpdb.ca/view/SMP0000302
    Drug action

    , heart rate and cardiac output. … Metoprolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure

    Drugs: ATP · Metoprolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  5. Pathway

    Pindolol Action Pathway

    smpdb.ca/view/SMP0000306
    Drug action

    Without renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.

    Drugs: ATP · Pindolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  6. Pathway

    Procainamide (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000324
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Procainamide · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  7. Pathway

    Fosphenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000326
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Phenytoin · Fosphenytoin · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  8. Pathway

    Tocainide Action Pathway

    smpdb.ca/view/SMP0000330
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Tocainide · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  9. Pathway

    Flecainide Action Pathway

    smpdb.ca/view/SMP0000331
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Flecainide · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  10. Pathway

    Ibutilide Action Pathway

    smpdb.ca/view/SMP0000332
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Ibutilide · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4