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Displaying results 141 - 150 of 2260 in total
  1. Drug

    Gepirone

    go.drugbank.com/drugs/DB12184
    Approved

    Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors.

    Categories: Serotonin Receptor Agonists
  2. Pathway

    Sphingolipid Signaling (Receptor)

    smpdb.ca/view/SMP0524344
    Signaling

    Through these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates … phosphate (S1P) is a potent bioactive lipid mediator synthesized intracellularly by the phosphorylation of sphingosine by sphingosine kinases SphK1 and SphK2 at the plasma membrane and is then exported via

    Drugs: Nitric oxide · Calcium · Magnesium cation
    Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4
  3. Drug

    Adenosine

    go.drugbank.com/drugs/DB00640
    ApprovedInvestigational

    The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though i...

    Mixtures: Vita Snail, Vita Solu Tion MaskCategories: Purinergic P1 Receptor Agonists
  4. Drug

    Recombinant human alkaline phosphatase

    go.drugbank.com/drugs/DB17672
    Investigational

    Synonyms: recAP
  5. Drug

    Ibutilide

    go.drugbank.com/drugs/DB00308
    Approved

    It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).

  6. Drug

    Olinvacimab

    go.drugbank.com/drugs/DB16265
    Investigational

    Olinvacimab is under investigation in clinical trial NCT03033524 (Trial to Evaluate the Safety of Ttac-0001(tanibirumab) in Recurrent Glioblastoma).

    Synonyms: Fully human monoclonal antibody targets vascular endothelial growth factor receptor 2, Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ttac-0001 heavy chain), disulfide with human monoclonal ttac-0001 light chain, dimer
  7. Drug

    Umespirone

    go.drugbank.com/drugs/DB20674
    Experimental

    The usage of the INN stem '-pirone' in the name indicates that Umespirone is a anxiolytic, buspirone derivative. Umespirone has a monoisotopic molecular weight of 512.3 Da.

    Categories: Serotonin Receptor Antagonists, Serotonin 5-HT1 Receptor Antagonists
  8. Drug

    Zalospirone

    go.drugbank.com/drugs/DB19481
    Experimental

    The usage of the INN stem '-pirone' in the name indicates that Zalospirone is a anxiolytic, buspirone derivative. Zalospirone has a monoisotopic molecular weight of 419.23 Da.

  9. Drug

    Alnespirone

    go.drugbank.com/drugs/DB19784
    Experimental

    The usage of the INN stem '-pirone' in the name indicates that Alnespirone is a anxiolytic, buspirone derivative. Alnespirone has a monoisotopic molecular weight of 442.28 Da.

    Categories: Serotonin Receptor Agonists
  10. Drug

    Eptapirone

    go.drugbank.com/drugs/DB19836
    Experimental

    The usage of the INN stem '-pirone' in the name indicates that Eptapirone is a anxiolytic, buspirone derivative. Eptapirone has a monoisotopic molecular weight of 345.19 Da.