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Displaying results 141 - 150 of 10000 in total
  1. Drug

    Capecitabine

    go.drugbank.com/drugs/DB01101
    ApprovedInvestigational

    Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.

    Synonyms: pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate, Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamateCategories: Heterocyclic Compounds, 1-Ring, Fluorouracil and prodrugs
  2. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) … It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual

    Synonyms: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, 5-acetamido-1,3,4-thiadiazole-2-sulfonamideCategories: Heterocyclic Compounds, 1-Ring, Antiglaucoma Preparations and Miotics
  3. Drug

    Tovorafenib

    go.drugbank.com/drugs/DB15266
    ApprovedInvestigational

    Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. … [A263602] Tovorafenib inhibits BRAF and blocks dysregulated signalling pathways related to cancer cell growth and survival.[L50587]

    Synonyms: 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-, 6-Amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamideCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 Inducers
  4. Drug

    5'-Fluoro-5'-Deoxyadenosine

    go.drugbank.com/drugs/DB03716
    Experimental

    Synonyms: 5'-Fluoro-5'-DeoxyadenosineCategories: Heterocyclic Compounds, 2-Ring, Nucleic Acids, Nucleotides, and Nucleosides
  5. Drug

    MK-8777

    go.drugbank.com/drugs/DB18904
    Investigational

    MK-8777 is under investigation in clinical trial NCT00610649 (Trial to Determine the Maximum Tolerated Dose (MTD) Based on Safety and Tolerability, of Org 26576 in Participants With Major Depressive Disorder … (174001/P05704/MK-8777-001)).

    Synonyms: 5H,7H-PYRIDO(3,2-F)PYRROLO(2,1-C)(1,4)OXAZEPIN-5-ONE, 8,9,9A,10-TETRAHYDRO-, (9AS)-Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Cyproheptadine

    go.drugbank.com/drugs/DB00434
    ApprovedInvestigational

    Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. … [L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.

    Synonyms: 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine, 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidineCategories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT2 Receptor Antagonists
  7. Drug

    Emtricitabine

    go.drugbank.com/drugs/DB00879
    ApprovedInvestigational

    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection … in high risk adolescents and adults.

    Synonyms: (−)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-oneMixtures: GENVOYA FILM COATED TABLET 150 MG/150 MG/200 MG/10 MG, DESCOVY (200/10 MG)
  8. Drug

    Talbutal

    go.drugbank.com/drugs/DB00306
    ApprovedIllicit

    Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.

    Synonyms: (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione, 5-allyl-5-sec-butylbarbituric acidCategories: Heterocyclic Compounds, 1-Ring, Hypnotics and Sedatives
  9. Drug

    5-methylcytidine 5'-monophosphate

    go.drugbank.com/drugs/DB01995
    Experimental

    Synonyms: 5-methylcytidine 5'-monophosphate, 5-methylcytidine-5'-monophosphateCategories: Heterocyclic Compounds, 1-Ring, Nucleic Acids, Nucleotides, and Nucleosides
  10. Drug

    Nitrazepam

    go.drugbank.com/drugs/DB01595
    Approved

    A benzodiazepine derivative used as an anticonvulsant and hypnotic.

    Synonyms: 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one, 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneCategories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedatives