DB00306ApprovedIllicitSmall molecule
Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
- Mechanism
- Curator reviewed
Talbutal binds to GABAA receptors at a distinct binding site associated with a Cl- ionopore of the receptor. Upon binding, talbutal increases the duration of time for which the Cl- ionopore is open, leading to prolonged inhibitory effect of GABA at the postsynaptic thalamic neuron.
- Primary indication
- For use as a sedative and hypnotic.Curator reviewed
- Formula / weight
- C11H16N2O3 · 224.2563 g/mol (avg)
- Also known as
- sec-Butyl allyl barbituric acid
- Code names
- HSDB 3397 · WIN 5095
Resolves to
Clinical / RWD
Structure
InChIKey
BJVVMKUXKQHWJK-UHFFFAOYSA-NSMILESCCC(C)C1(CC=C)C(=O)NC(=O)NC1=OWhat you can answer from here — as of September 23, 2026
12Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Talbutal, and which of those have an active Phase 3 trial?
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