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Ketorolac NSAID Action Pathway
smpdb.ca/view/SMP0124627Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Because ketorolac decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects result in increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthaseFlurbiprofen NSAID Action Pathway
smpdb.ca/view/SMP0124634Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because Flurbiprofen decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects result in increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthaseDexibuprofen Action Pathway
smpdb.ca/view/SMP0126112Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Because dexibuprofen decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +1 moreEnzymes: Prostaglandin E synthaseHelium
go.drugbank.com/drugs/DB09155ApprovedInvestigationalVet approvedHelium is a second most abundant chemical element in the universe with symbol He and atomic number 2. … It is also used as an analytical reagent in diagnostic/imaging tests to detect respiratory function of the patient.
Mixtures: Oxygen In Helium Mix, Oxygen In Helium MixtureSynonyms: [He]Lamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalA reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. … It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Synonyms: beta-L-2',3'-Dideoxy-3'-thiacytidine, beta-L-3'-Thia-2',3'-dideoxycytidineMixtures: N/A, N/AVinflunine
go.drugbank.com/drugs/DB11641ApprovedInvestigationalIn 2009, vinflunine was approved by the European Medicines Agency (EMA) as a second-line therapy of metastatic and advanced urothelial cancer after failure of platinum-based treatment [A32626]. … Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 20',20'-difluoro-3',4'-dihydrovinorelbine, 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastineDuvelisib
go.drugbank.com/drugs/DB11952ApprovedInvestigationalDuvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma … All the work around duvelisib showed that this agent is a potent inhibitor of both forms.[A39025] Duvelisib was developed by Verastem, Inc and FDA approved on September 24, 2018.[L4585]
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCalcium acetate
go.drugbank.com/drugs/DB00258ApprovedThe anhydrous form is very hygroscopic, therefore the monohydrate is the common form. … The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime.
Synonyms: calcium(II) acetateMixtures: DOMEBORO® POLVO, ACETATO DE ALUMINIOTrihexyphenidyl
go.drugbank.com/drugs/DB00376ApprovedInvestigational[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects. … [L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.
International brands: Ea TenCategories: Heterocyclic Compounds, 1-RingCupric Chloride
go.drugbank.com/drugs/DB09131ApprovedCupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Mixtures: Tracel Injektionslösung in einer Fertigspritze, ADDAMEL NSynonyms: copper(II) chloride, Copper(2+) chloride