Cupric Chloride

Identification

Name
Cupric Chloride
Accession Number
DB09131
Description

Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 134.452
Monoisotopic: 132.867306493
Chemical Formula
Cl2Cu
Synonyms
  • Copper chloride
  • Copper(2+) chloride
  • copper(II) chloride
  • Cupric chloride anhydrous

Pharmacology

Pharmacology
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Indication

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Copper is an essential nutrient which serves as a co factor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation. Providing copper during Total Parenteral Nutrition helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.

Mechanism of action

The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.

TargetActionsOrganism
UVitamin K-dependent protein CNot AvailableHumans
UCystatin-BNot AvailableHumans
Absorption

Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)

Volume of distribution

Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound.
Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 µg/g wet weight respectively)

Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Renal

Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity

LD50 not available Copper toxicity can produce prostration, behavior change, diarrhea, progressive marasmus, hypotonia, photophobia and peripheral edema. Such symptoms have been reported with a serum copper level of 286 mcg/dl. Copper toxicity can also result in hemolysis and liver toxicity, including hepatic necrosis which may be fatal. D-penicillamine has been reported effective as an antidote.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Cupric chloride dihydrateS2QG84156O10125-13-0MPTQRFCYZCXJFQ-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
Cupric cationionic8CBV67279L15158-11-9JPVYNHNXODAKFH-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CopperInjection, solution0.4 mg/1mLIntravenousHospira, Inc.2005-02-28Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ADDAMEL INFUSION NCupric chloride dihydrate (3.4 mg) + Chromic chloride hexahydrate (53.3 mcg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium selenite pentahydrate (105 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)Solution, concentrateIntravenous2006-11-102009-05-08Colombia flag
AddnutrivCupric Chloride (380 mcg) + Chromic chloride (10 mcg) + Ferric chloride (1100 mcg) + Manganese (55 mcg) + Potassium Iodide (130 mcg) + Sodium selenite (79 mcg) + Sodium fluoride (950 mcg) + Sodium molybdate (19 mcg) + Zinc (5000 mcg)SolutionIntravenousFresenius Kabi2020-12-01Not applicableCanada flag
NULANZA® SOLUCION CONCENTRADA PARA INFUSION.Cupric chloride dihydrate (1023 mcg) + Chromic chloride hexahydrate (53.3 mcg) + Ferric chloride hexahydrate (5400 mcg) + Manganese chloride tetrahydrate (197.9 mcg) + Potassium Iodide (166 mcg) + Sodium selenite (172.9 mcg) + Sodium fluoride (2100 mcg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (10.5 mg)Solution, concentrateIntravenous2016-08-03Not applicableColombia flag
PEDITRACECupric Chloride (53.7 mcg/ml) + Manganese chloride (3.6 mcg/ml) + Potassium Iodide (1.31 mcg/ml) + Sodium selenite (4.38 mcg/ml) + Sodium fluoride (126 mcg/ml) + Zinc chloride (521 mcg/ml)Injection, solution, concentrateParenteralFRESENIUS KABI MALAYSIA SDN. BHD2020-09-08Not applicableMalaysia flag
Trace Elements for Injection - Liq IVCupric Chloride (2.68 mg) + Chromic chloride (.102 mg) + Manganese chloride (1.44 mg) + Zinc chloride (10.42 mg)LiquidIntravenousFaulding Consumer, Inc.1998-06-152001-07-30Canada flag
Trace Elements Injection USPCupric Chloride (0.42 mg) + Chromic chloride (6 mcg) + Manganese chloride (0.37 mg) + Zinc chloride (1.67 mg)SolutionIntravenousPfizer Canada Ulc1983-12-312020-01-16Canada flag
Trace Elements Solution InjCupric Chloride (2.68 mg) + Chromic chloride (.102 mg) + Manganese chloride (1.44 mg) + Zinc chloride (10.42 mg)SolutionIntravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311998-08-13Canada flag
TRACUTIL® 10 ML AMPOLLASCupric chloride dihydrate (2.046 mg) + Chromic chloride hexahydrate (0.053 mg) + Ferrous chloride tetrahydrate (6.958 mg) + Manganese chloride tetrahydrate (1.979 mg) + Potassium Iodide (0.166 mg) + Sodium selenite pentahydrate (0.0789 mg) + Sodium fluoride (1.26 mg) + Sodium molybdate dihydrate (0.0242 mg) + Zinc chloride (6.815 mg)Solution, concentrateIntravenous2006-11-102015-08-10Colombia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ADDAMEL N 20 AMPULCupric Chloride (3.4 mg/10mL) + Chromic chloride (53.3 mcg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYONCupric Chloride (1.02 mg/10mL) + Chromic chloride (53.3 mcg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag
PeditraceCupric chloride dihydrate (20 ug/1mL) + Manganese chloride tetrahydrate (1 ug/1mL) + Potassium Iodide (1 ug/1mL) + Sodium selenite (2 ug/1mL) + Sodium fluoride (57 ug/1mL) + Zinc chloride (250 ug/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-092016-08-31US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal salts
Sub Class
Transition metal chlorides
Direct Parent
Transition metal chlorides
Alternative Parents
Inorganic chloride salts
Substituents
Inorganic chloride salt / Inorganic salt / Transition metal chloride
Molecular Framework
Not Available
External Descriptors
inorganic chloride, copper molecular entity (CHEBI:49553)

Chemical Identifiers

UNII
P484053J2Y
CAS number
7447-39-4
InChI Key
ORTQZVOHEJQUHG-UHFFFAOYSA-L
InChI
InChI=1S/2ClH.Cu/h2*1H;/q;;+2/p-2
IUPAC Name
dichlorocopper
SMILES
Cl[Cu]Cl

References

General References
  1. Pubchem [Link]
  2. inChem [Link]
PubChem Compound
24014
PubChem Substance
310265046
ChemSpider
22447
RxNav
150596
ChEBI
49553
ChEMBL
CHEMBL1200553
PDBe Ligand
CUL
PDB Entries
1d40

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1TerminatedTreatmentProstate Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravenous drip
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous0.4 mg/1mL
SolutionIntravenous
Solution, concentrateIntravenous
Injection, solutionIntravenous
Injection, solution, concentrateIntravenous; Parenteral
Injection, solution, concentrateParenteral
LiquidIntravenous
Injection, solutionParenteral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.52ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity12.27 m3·mol-1ChemAxon
Polarizability7.27 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine-type endopeptidase activity
Specific Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts ...
Gene Name
PROC
Uniprot ID
P04070
Uniprot Name
Vitamin K-dependent protein C
Molecular Weight
52070.82 Da
References
  1. Bar-Or D, Rael LT, Winkler JV, Yukl RL, Thomas GW, Shimonkevitz RP: Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1388-92. [PubMed:11820775]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Specific Function
Cysteine-type endopeptidase inhibitor activity
Gene Name
CSTB
Uniprot ID
P04080
Uniprot Name
Cystatin-B
Molecular Weight
11139.555 Da
References
  1. Zerovnik E, Skerget K, Tusek-Znidaric M, Loeschner C, Brazier MW, Brown DR: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation. FEBS J. 2006 Sep;273(18):4250-63. [PubMed:16939620]

Drug created on September 29, 2015 17:37 / Updated on June 12, 2020 16:52