Identification
- Summary
Cupric Chloride is a transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).
- Generic Name
- Cupric Chloride
- DrugBank Accession Number
- DB09131
- Background
Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Cupric Chloride (DB09131)
- Weight
- Average: 134.452
Monoisotopic: 132.867306493 - Chemical Formula
- Cl2Cu
- Synonyms
- Copper chloride
- Copper(2+) chloride
- copper(II) chloride
- Cupric chloride anhydrous
Pharmacology
- Indication
For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Copper is an essential nutrient which serves as a co factor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation. Providing copper during Total Parenteral Nutrition helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.
- Mechanism of action
The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.
Target Actions Organism UVitamin K-dependent protein C Not Available Humans UCystatin-B Not Available Humans - Absorption
Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)
- Volume of distribution
Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound.
Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 µg/g wet weight respectively)- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Renal
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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LD50 not available Copper toxicity can produce prostration, behavior change, diarrhea, progressive marasmus, hypotonia, photophobia and peripheral edema. Such symptoms have been reported with a serum copper level of 286 mcg/dl. Copper toxicity can also result in hemolysis and liver toxicity, including hepatic necrosis which may be fatal. D-penicillamine has been reported effective as an antidote.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
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Ingredient UNII CAS InChI Key Cupric chloride dihydrate S2QG84156O 10125-13-0 MPTQRFCYZCXJFQ-UHFFFAOYSA-L - Active Moieties
Name Kind UNII CAS InChI Key Cupric cation ionic 8CBV67279L 15158-11-9 JPVYNHNXODAKFH-UHFFFAOYSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Copper Injection, solution 0.4 mg/1mL Intravenous Hospira, Inc. 2005-02-28 Not applicable US 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ADDAMEL INFUSION N Cupric chloride dihydrate (3.4 mg) + Chromic chloride hexahydrate (53.3 mcg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium selenite pentahydrate (105 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg) Solution, concentrate Intravenous FRESENIUS KABI COLOMBIA S.A.S. 2006-11-10 2009-05-08 Colombia 
ADDAMEL N FOR INFUSION Cupric chloride dihydrate (0.34 mg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (99 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium selenite (6.9 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.36 mg/ml) Injection Intravenous FRESENIUS KABI (SINGAPORE) PTE LTD 1992-01-31 Not applicable Singapore ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSION Cupric chloride dihydrate (102.3 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Ferric chloride hexahydrate (540 mcg/ml) + Manganese chloride tetrahydrate (19.79 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium selenite (17.29 mcg/ml) + Sodium fluoride (210 mcg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1050 mcg/ml) Solution Intravenous FRESENIUS KABI (SINGAPORE) PTE LTD 2017-07-24 Not applicable Singapore Addaven Konzentrat zur Herstellung einer Infusionslösung Cupric chloride dihydrate (0.1 mg/ml) + Chromic chloride hexahydrate (5.33 μg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (19.8 μg/ml) + Potassium Iodide (16.6 μg/ml) + Sodium selenite (17.3 μg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 μg/ml) + Zinc chloride (1.05 mg/ml) Injection, solution, concentrate Intravenous Fresenius Kabi Austria Gmb H 2015-03-02 Not applicable Austria 
Addnutriv Cupric Chloride (380 mcg / 10 mL) + Chromic chloride (10 mcg / 10 mL) + Ferric chloride (1100 mcg / 10 mL) + Manganese chloride (55 mcg / 10 mL) + Potassium Iodide (130 mcg / 10 mL) + Sodium selenite (79 mcg / 10 mL) + Sodium fluoride (950 mcg / 10 mL) + Sodium molybdate (19 mcg / 10 mL) + Zinc chloride (5000 mcg / 10 mL) Solution Intravenous Fresenius Kabi 2020-12-01 Not applicable Canada 
Elotrace - Infusionszusatz Cupric Chloride (32.19 mg/L) + Calcium chloride (5.881 g/L) + Ferric chloride (53.24 mg/L) + Magnesium chloride hexahydrate (10.166 g/L) + Manganese chloride (10.81 mg/L) + Potassium Iodide (1.66 g/L) + Potassium hydroxide (39.607 g/L) + Sodium selenite (2.63 mg/L) + Sodium fluoride (21 g/L) + Sodium glycerophosphate (107.142 g/L) + Sodium molybdate (0.5 mg/L) + Zinc chloride (125.07 mg/ml) Solution Intravenous Fresenius Kabi Austria Gmb H 1996-05-15 Not applicable Austria Nutritrace Concentrate for solution for infusion Cupric chloride dihydrate (2.046 mg/10ml) + Chromic chloride hexahydrate (0.053 mg/10ml) + Ferrous chloride tetrahydrate (6.958 mg/10ml) + Manganese chloride tetrahydrate (1.979 mg/10ml) + Potassium Iodide (0.166 mg/10ml) + Sodium selenite pentahydrate (0.0789 mg/10ml) + Sodium fluoride (1.26 mg/10ml) + Sodium molybdate dihydrate (0.0242 mg/10ml) + Zinc chloride (6.815 mg/10ml) Solution Intravenous B. BRAUN SINGAPORE PTE LTD 2013-04-22 Not applicable Singapore PEDITRACE Cupric Chloride (53.7 mcg/ml) + Manganese chloride (3.6 mcg/ml) + Potassium Iodide (1.31 mcg/ml) + Sodium selenite (4.38 mcg/ml) + Sodium fluoride (126 mcg/ml) + Zinc chloride (521 mcg/ml) Injection, solution, concentrate Parenteral FRESENIUS KABI MALAYSIA SDN. BHD 2020-09-08 Not applicable Malaysia 
Peditrace - Infusionszusatz Cupric Chloride (537 μg/10ml) + Manganese chloride (36 μg/10ml) + Potassium Iodide (13.1 μg/10ml) + Sodium selenite (43.8 μg/10ml) + Sodium fluoride (1.26 mg/10ml) + Zinc chloride (5.21 mg/10ml) Solution Intravenous Fresenius Kabi Austria Gmb H 1995-03-24 Not applicable Austria PEDITRACE (ELEMENTOS TRAZA PEDIATRICOS) Cupric chloride dihydrate (53.7 mcg) + Manganese chloride tetrahydrate (3.6 mcg) + Potassium Iodide (1.31 mcg) + Sodium selenite pentahydrate (6.66 mcg) + Sodium fluoride (126 mcg) + Zinc chloride (521 mcg) Solution, concentrate Intravenous FRESENIUS KABI COLOMBIA S.A.S 2006-11-10 2010-03-29 Colombia - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ADDAMEL N 20 AMPUL Cupric Chloride (3.4 mg/10mL) + Chromic chloride (53.3 mcg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL) Injection, solution Intravenous FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 Not applicable Turkey 
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYON Cupric Chloride (1.02 mg/10mL) + Chromic chloride (53.3 mcg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL) Injection, solution Intravenous FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 Not applicable Turkey Peditrace Cupric chloride dihydrate (20 ug/1mL) + Manganese chloride tetrahydrate (1 ug/1mL) + Potassium Iodide (1 ug/1mL) + Sodium selenite (2 ug/1mL) + Sodium fluoride (57 ug/1mL) + Zinc chloride (250 ug/1mL) Injection, solution Intravenous Fresenius Kabi USA, LLC 2013-05-09 2016-08-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Transition metal salts
- Sub Class
- Transition metal chlorides
- Direct Parent
- Transition metal chlorides
- Alternative Parents
- Inorganic chloride salts
- Substituents
- Inorganic chloride salt / Inorganic salt / Transition metal chloride
- Molecular Framework
- Not Available
- External Descriptors
- inorganic chloride, copper molecular entity (CHEBI:49553)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- P484053J2Y
- CAS number
- 7447-39-4
- InChI Key
- ORTQZVOHEJQUHG-UHFFFAOYSA-L
- InChI
- InChI=1S/2ClH.Cu/h2*1H;/q;;+2/p-2
- IUPAC Name
- dichlorocopper
- SMILES
- Cl[Cu]Cl
References
- General References
- External Links
- PDB Entries
- 1d40
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Terminated Treatment Prostate Cancer 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution, concentrate Intravenous Injection Intravenous 5.33 mcg/ml Injection, solution Intravenous drip Solution Intravenous 5.33 mcg/ml Injection, solution Intravenous 0.4 mg/1mL Solution Intravenous Solution Intravenous 0.053 mg/10ml Injection, solution Intravenous Injection, solution, concentrate Intravenous; Parenteral Injection, solution, concentrate Parenteral Solution, concentrate Intravenous Injection Intravenous Liquid Intravenous Injection, solution Parenteral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 44.6 mg/mL ALOGPS logP 0.94 ALOGPS logP 0.52 Chemaxon logS -0.48 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 12.27 m3·mol-1 Chemaxon Polarizability 7.27 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts ...
- Gene Name
- PROC
- Uniprot ID
- P04070
- Uniprot Name
- Vitamin K-dependent protein C
- Molecular Weight
- 52070.82 Da
References
- Bar-Or D, Rael LT, Winkler JV, Yukl RL, Thomas GW, Shimonkevitz RP: Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1388-92. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
- Specific Function
- Cysteine-type endopeptidase inhibitor activity
- Gene Name
- CSTB
- Uniprot ID
- P04080
- Uniprot Name
- Cystatin-B
- Molecular Weight
- 11139.555 Da
References
- Zerovnik E, Skerget K, Tusek-Znidaric M, Loeschner C, Brazier MW, Brown DR: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation. FEBS J. 2006 Sep;273(18):4250-63. [Article]
Drug created at September 29, 2015 17:37 / Updated at June 12, 2020 16:52