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Allylestrenol
go.drugbank.com/drugs/DB01431InvestigationalA synthetic steroid with progestational activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 17α-allylestr-4-en-17β-ol, 3-deketo-17α-allyl-19-nortestosteroneVinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalIt was initially approved in the USA in 1990's for the treatment of NSCLC [L2010]. It is a third-generation vinca alkaloid. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.
Synonyms: 5'-NoranhydrovinblastineCategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesDemeclocycline
go.drugbank.com/drugs/DB00618ApprovedA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Synonyms: 6-demethyl-7-chlorotetracycline, 7-chloro-6-demethyltetracyclineMephenesin
go.drugbank.com/drugs/DB13583ApprovedWithdrawnMephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression [A32760]. It first entered use in the 1950s.
Synonyms: 3-(O-METHYLPHENOXY)-1,2-PROPANEDIOLOmaveloxolone
go.drugbank.com/drugs/DB12513ApprovedInvestigational[L51654], [L52595] The use of omaveloxolone for the treatment of conditions involving mitochondrial dysfunction and oxidative stress has also been evaluated.[A257534,A257559] … [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress.
Categories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 SubstratesSynonyms: Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-Salicylamide
go.drugbank.com/drugs/DB08797ApprovedSalicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties.
Mixtures: Green Guard Pain and Ache Relief, CON-Z-LIN TABLETCategories: Non COX-2 selective NSAIDSAmitriptylinoxide
go.drugbank.com/drugs/DB13114ApprovedWithdrawnAmitriptylinoxide has been used in trials studying Major Depression.
Cinnarizine
go.drugbank.com/drugs/DB00568ApprovedInvestigationalCinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. … Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine, 1-Benzhydryl-4-cinnamylpiperazinGallium Ga-68 gozetotide
go.drugbank.com/drugs/DB16019ApprovedInvestigational[A225396] In nearly all prostate cancers, malignant cells express a transmembrane protein called prostate-specific membrane antigen (PSMA). … Gallium (Ga) 68 prostate-specific membrane antigen (PSMA)-11, or Ga-68 gozetotide, is a radiopharmaceutical agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions
Categories: Compounds used in a research, industrial, or household settingTrastuzumab
go.drugbank.com/drugs/DB00072ApprovedInvestigationaladenocarcinoma) whose tumors overexpress the HER2 gene (HER2+). … It is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal
Mixtures: PHESGO® 600MG/600MG, PHESGO® 600MG/600MGCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors, HER2 Receptor Antagonists