Mephenesin

DB13583ApprovedWithdrawnSmall molecule

Mephenesin is a cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis. Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression.

Mechanism: The exact mechanism of action of mephenesin is not known. It has been observed to block both inward sodium and inward calcium currents in neurons. It has a physiological effect which opposes that of strychnine.
Curator reviewed · 1 reference
Primary indication: Mephenesin was used for the treatment of muscle spasticity in diseases like Parkinson's or Multiple Sclerosis.Curator reviewed
Formula / weight: C₁₀H₁₄O₃ · 182.219 g/mol (avg)
First approval: Canada, 1962
Also known as: 3-(O-METHYLPHENOXY)-1,2-PROPANEDIOL · TOLSEROL
Code names: NSC-25234

Resolves to

Compound

UNII7B8PIR2954CAS59-47-2ChEMBLCHEMBL229128ChEBI94398PubChem4059

Clinical / RWD

RxNorm6755ATCM03BX06

Structure

InChIKeyJWDYCNIAQWPBHD-UHFFFAOYSA-NSMILESCC1=CC=CC=C1OCC(O)CO

What you can answer from here — as of September 23, 2026

16Drug interactionsStructured to mechanism, not free text

1Marketed productAcross 1 country and 1 labeller

1ATC codeIncluding every combination product, plus 10 drug categories

3+ReferencesStructured and connected to the statements they support

Which companies are running trials of Mephenesin, in which indications and phases, and which of those programs are still active?

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