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Mogamulizumab
go.drugbank.com/drugs/DB12498ApprovedInvestigationalMogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of … [L4168] It was approved for the same indications in Canada in June 2022.
Categories: Chemokine Receptor Type 4 Interaction, Chemokine Receptor Type 4 InteractionsSpinosad
go.drugbank.com/drugs/DB08823ApprovedVet approvedto many investigations for use in other animals and agricultural plants. … Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition
Mixtures: Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 9.1-18kg, Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 18.1-27kgPentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for … [A226410, A226415, A226455] More recently, PTX has been suggested as a possible treatment for COVID-19-induced pulmonary complications due to its ability to regulate the production of inflammatory cytokines
Categories: Drugs for Obstructive Airway Diseases, Cytochrome P-450 SubstratesInternational brands: An Ruo NingEthionamide
go.drugbank.com/drugs/DB00609ApprovedInvestigationalWithdrawnIt also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisTrandolapril
go.drugbank.com/drugs/DB00519ApprovedInvestigationalTrandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment … Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Categories: Antihypertensive Agents Indicated for HypertensionMethsuximide
go.drugbank.com/drugs/DB05246ApprovedMesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InhibitorsTrimethadione
go.drugbank.com/drugs/DB00347ApprovedWithdrawnAn anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesEsterified estrogens
go.drugbank.com/drugs/DB09381ApprovedIt is being also for the prevention and treatment of osteoporosis. … Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFlibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalin the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. … Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSodium ferric gluconate complex
go.drugbank.com/drugs/DB09517ApprovedSodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. … The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography.