Sodium ferric gluconate complex

DB09517ApprovedSmall moleculeIron Preparations Parenteral Iron Replacement

Sodium ferric gluconate complex is an iron complex used for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography.

Mechanism: The complex is endocytosed by macrophages of the reticuloendothelial system. Within an endosome of the macrophage, lysosome fuses with the endosome creating an acidic environment leading to the cleavage of the complex from iron. Iron is then incorporated in ferritin, transferrin or hemoglobin. Sodium ferric gluconate also normalizes RBC production by binding with hemoglobin
Curator reviewed
Primary indication: Sodium ferric gluconate complex in sucrose injection is used to deplete the total body content of iron during iron deficiency anemia in patients aged 6 years and older with chronic kidney disease receiving hemodialysis and...Curator reviewed · 2 structured indications
Formula / weight: C₆₆H₁₂₁Fe₂NaO₆₅ · 2089.309 g/mol (avg)
First approval: Canada, 2010 · United States, 1999
Also known as: Ferric sodium gluconate complex · Sodium Ferric Gluconate
Brand names: Ferrlecit

Resolves to

Compound

UNIICC9149U2QXCAS34089-81-1PubChem76968835

Clinical / RWD

RxNorm261435

Structure

InChIKeyMQBDAEHWGRMADS-XNHLMZCASA-MSMILES

[O--].[O--].[O--].[Na+].[Fe+3].[Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O

Targets

P02792FTLP68871HBBP69905HBA1

What you can answer from here — as of April 10, 2025

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

265Drug interactionsStructured to mechanism, not free text

16Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

2ContraindicationsEach with its own population and attribute set

20Marketed productsAcross 3 countries and 8 labellers

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sodium ferric gluconate complex, and which of those have an active Phase 3 trial?

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