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Phosphocreatine
go.drugbank.com/drugs/DB13191InvestigationalNutraceuticalPhosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. It is primarily found endogenously in the skeletal muscles of vertebrates where it serves a critical role as a rapidly acting energy buffer for muscle cell...
Sirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[A242372] The topical formulation of sirolimus, marketed as HYFTOR, was approved by the FDA in April 2022: this marks the first topical treatment approved in the US for facial angiofibroma associated with … [A1320] Sirolimus was first approved by the FDA in 1999 for the prophylaxis of organ rejection in patients aged 13 years and older receiving renal transplants.
Vadadustat
go.drugbank.com/drugs/DB12255ApprovedInvestigational[A244165] A relatively new and alternative treatment option for patients with anemia associated with CKD is the use of small molecule inhibitors of hypoxia-inducible factor prolyl-hydroxylase (HIF-PH … [L39610,L46936,L46951] Vadadustat was approved by the FDA in March 2024.[L50371]
Enfortumab vedotin
go.drugbank.com/drugs/DB13007ApprovedInvestigationalThe clinical development of enfortumab vedotin was the result of a collaboration between Astellas Pharma and Seattle Genetics [A188868] and it was first approved for use in the United States in December … [L10836] Enfortumab vedotin was later approved by the European Commission on April 13, 2022.[L42000]
Iophendylate
go.drugbank.com/drugs/DB01187ApprovedIophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. … It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography.
NP2
go.drugbank.com/drugs/DB06308InvestigationalNP2 is a replication defective HSV-1 based gene transfer vector engineered to express human preproenkephalin. It was under investigation in clinical trial NCT01291901 (NP2 Enkephalin For Treatment of Intractable Cancer Pain).
Methysergide
go.drugbank.com/drugs/DB00247ApprovedWithdrawnIt antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids.
Serdexmethylphenidate
go.drugbank.com/drugs/DB16629Approved[A230698, A230703] The underlying cause of ADHD is unclear but likely involves dysfunction in dopaminergic and noradrenergic neurotransmission, as evidenced by the clear beneficial effect of CNS stimulants … Attention Deficit Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and is characterized by developmentally inappropriate and impaired attention
Aluminum oxide
go.drugbank.com/drugs/DB11342ApprovedWithdrawnIt is considered an indirect additive used in food contact substances by the FDA.
Categories: Anti-Acne Preparations for Topical UsePeginterferon alfa-2a
go.drugbank.com/drugs/DB00008ApprovedInvestigationalThe use of Peginterferon alfa-2a has largely declined since newer interferon-free antiviral therapies have been developed. … Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) resulting in less use of Peginterferon alfa-2a.