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Trioxsalen
go.drugbank.com/drugs/DB04571ApprovedWithdrawnIn research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be … It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema.
Categories: Antipsoriatics for Systemic Use, Antipsoriatics for Topical UseLanolin
go.drugbank.com/drugs/DB11112ApprovedThe US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments [L2583]. … Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers [L2583], [A32788].
Mixtures: Kendra SKIN PROTECTION and PAIN RELIEF FOR HAIR REMOVAL, Skullduggery Pain Relief and Skin Protection for TattoosDrospirenone
go.drugbank.com/drugs/DB01395ApprovedInvestigational[L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy. … Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.
Categories: Hormonal Contraceptives for Systemic Use, Cytochrome P-450 SubstratesFormestane
go.drugbank.com/drugs/DB08905ApprovedWithdrawnIt is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. … Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersTechnetium Tc-99m exametazime
go.drugbank.com/drugs/DB09163ApprovedIt can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. … Exametazime, also known as hexamethylpropyleneamine oxime or HMPAO, acts as a chelating agent for the Tc-99m radioisotope.
Chloroprocaine
go.drugbank.com/drugs/DB01161ApprovedInvestigationalBoth can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks. … [A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.[L43387]
Ciltacabtagene autoleucel
go.drugbank.com/drugs/DB16738ApprovedInvestigationalIt is a rare malignancy, with an estimated yearly incidence of 6.5 people per 100,000,[L40749] and is variable in its presentation - some patients may remain entirely asymptomatic, while others may experience … [A245854] B-cell maturation antigen (BCMA) is a transmembrane glycoprotein member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17) which is used as a biomarker for multiple myeloma.
Spirapril
go.drugbank.com/drugs/DB01348ApprovedInvestigationalSpirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration.
Generalized Convulsive Epilepsy
go.drugbank.com/conditions/DBCOND0031733Drugs: ValpromideSynonyms: Grand mal, Grand mal fitDarolutamide
go.drugbank.com/drugs/DB12941ApprovedInvestigationalDarolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). … [A189063] Though prior treatment for prostate cancer has been successful for these patients, the cancer eventually progresses to become resistant to existing therapies.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates