Chloroprocaine is a local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, spinal anesthesia, or ocular surface anesthesia. Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride.
- Mechanism
- Curator reviewed · 6 references
Chloroprocaine acts mainly by binding to the alpha subunit on the cytoplasmic region of voltage-gated sodium channels and inhibiting sodium influx in neuronal cell membranes. This lowers the nerve membrane permeability to sodium and decreases the rate of rise of the action potential. Therefore, chloroprocaine inhibits signal conduction and leads to a reversible nerve conduction blockade. The progression of anesthesia depends on the diameter, myelination and conduction velocity of nerve fibers, and the order of loss of nerve function is the following: 1) pain, 2) temperature, 3) touch, 4) proprioception, and 5) skeletal muscle tone.
- Primary indication
- Chloroprocaine for intrathecal injection is indicated for the production of subarachnoid block (spinal anesthesia) in adults.Curator reviewed · 7 structured indications
- Formula / weight
- C13H19ClN2O2 · 270.755 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1990
- Also known as
- 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate · Chloroprocain · Chlorprocaine
- Brand names
Resolves to
VDANGULDQQJODZ-UHFFFAOYSA-NSMILESCCN(CC)CCOC(=O)C1=C(Cl)C=C(N)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Chloroprocaine, and which of those have an active Phase 3 trial?
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