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Displaying results 1541 - 1550 of 8696 in total
  1. Drug

    Leucovorin

    go.drugbank.com/drugs/DB00650
    ApprovedInvestigational

    [L56091, A257419] Leucovorin has been explored experimentally for autism spectrum disorder.[A275451, A275452] … [L56092, A257419] Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate

    Mixtures: EnBrace HRCategories: Detoxifying Agents for Antineoplastic Treatment
  2. Drug

    Drospirenone

    go.drugbank.com/drugs/DB01395
    ApprovedInvestigational

    [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy. … Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.

    Categories: Hormonal Contraceptives for Systemic Use, Cytochrome P-450 Substrates
  3. Drug

    Technetium Tc-99m exametazime

    go.drugbank.com/drugs/DB09163
    Approved

    It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. … Exametazime, also known as hexamethylpropyleneamine oxime or HMPAO, acts as a chelating agent for the Tc-99m radioisotope.

  4. Drug

    Ciltacabtagene autoleucel

    go.drugbank.com/drugs/DB16738
    ApprovedInvestigational

    It is a rare malignancy, with an estimated yearly incidence of 6.5 people per 100,000,[L40749] and is variable in its presentation - some patients may remain entirely asymptomatic, while others may experience … [A245854] B-cell maturation antigen (BCMA) is a transmembrane glycoprotein member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17) which is used as a biomarker for multiple myeloma.

  5. Drug

    Spirapril

    go.drugbank.com/drugs/DB01348
    ApprovedInvestigational

    Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration.

  6. Drug

    Lanolin

    go.drugbank.com/drugs/DB11112
    Approved

    The US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments [L2583]. … Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers [L2583], [A32788].

    Mixtures: Kendra SKIN PROTECTION and PAIN RELIEF FOR HAIR REMOVAL, Skullduggery Pain Relief and Skin Protection for Tattoos
  7. Indication

    Generalized Convulsive Epilepsy

    go.drugbank.com/conditions/DBCOND0031733
    Drugs: Valpromide
    Synonyms: Grand mal, Grand mal fit
  8. Drug

    Darolutamide

    go.drugbank.com/drugs/DB12941
    ApprovedInvestigational

    Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). … [A189063] Though prior treatment for prostate cancer has been successful for these patients, the cancer eventually progresses to become resistant to existing therapies.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  9. Drug

    Chloroprocaine

    go.drugbank.com/drugs/DB01161
    ApprovedInvestigational

    Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks. … [A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.[L43387]

  10. Drug

    Trioxsalen

    go.drugbank.com/drugs/DB04571
    ApprovedWithdrawn

    In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be … It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema.

    Categories: Antipsoriatics for Systemic Use, Antipsoriatics for Topical Use