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Lotilaner
go.drugbank.com/drugs/DB17992ApprovedInvestigationalVet approved[A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active _in vivo_, while the R-enantiomer is reported to exhibit low biological activity. … The active ingredient found in drug products of lotilaner is the S-enantiomer.
Synonyms: 2-thiophenecarboxamide, 5-((5s)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl)-3-methyl-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-, 3-methyi-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-((55)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)thiophene-2-carboxamideCategories: Heterocyclic Compounds, 1-RingCalaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalCalaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. … SC) linker to create a stable molecule which increases the half-life and decreases the dosing frequency [FDA label], [A40270].
Categories: L-asparaginase containing drugs, Compounds used in a research, industrial, or household settingNonivamide
go.drugbank.com/drugs/DB11324ApprovedNonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and _vanillylamine_. … It is naturally found in chili peppers but manufactured to produce a synthetic form for various pharmacologic preparations [L2641].
Synonyms: N-Vanillylnonamide, N-Nonanoyl vanillylamideMixtures: Nonivamid + Nicoboxil Zentiva 4 mg/g + 25 mg/g SalbeSolriamfetol
go.drugbank.com/drugs/DB14754ApprovedInvestigationalSolriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated
Categories: MATE 1 Inhibitors, MATE 1 SubstratesSynonyms: (2R)-2-amino-3-phenylpropyl carbamateLevothyroxine
go.drugbank.com/drugs/DB00451ApprovedInvestigationaldeiodination (by type I or type II 5′-deiodinases)[A179941] into its active metabolite T<sub>3</sub>. … Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland.
Synonyms: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine, 3,5,3',5'-Tetraiodo-L-thyronineMixtures: L THYROX JOD HEXAL 50/150, L THYROX JOD HEXAL 50/150Lurasidone
go.drugbank.com/drugs/DB08815ApprovedInvestigationalLurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: LURAP® 40, LURAP ® 80Glecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalGlecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. … In combination with [DB13878], glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors.
Mixtures: MAVIRET® 100/40 MG TABLETAS RECUBIERTASCategories: P-glycoprotein inhibitors, P-glycoprotein substratesFlavin mononucleotide
go.drugbank.com/drugs/DB03247ApprovedInvestigationalFlavin mononucleotide (FMN), also known as riboflavin 5'-phosphate, is one of the two major coenzymes derived from [riboflavin] (vitamin B2) and is one of the principal forms in which dietary riboflavin … is found.
Salts: Riboflavin 5'-phosphate sodium anhydrous, Riboflavin-5'-phosphate sodium salt dihydrateMixtures: Alsimine W Vitamins A D, B Complex W C and B12 InjAripiprazole lauroxil
go.drugbank.com/drugs/DB14185ApprovedIt is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors [A34289]. … Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsTetraferric tricitrate decahydrate
go.drugbank.com/drugs/DB14520ApprovedInvestigational[A25965] Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014.[L9926] … Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease.
Products: FERRISITA 107,7 MG/5 ML SURUP, 150 ML