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Displaying results 1581 - 1590 of 10000 in total

Target
Nitric oxide synthase, inducible
go.drugbank.com/bio_entities/BE0000005
TargetEnzymeHumans
In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). … Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706).
Synonyms: Inducible NO synthase
Drug
Gabexate
go.drugbank.com/drugs/DB12831
Investigational
Gabexate has been investigated for use in cancer, ischemia-reperfusion injury, and pancreatitis.[A19218,A19219,A19220] … Gabexate is a synthetic serine protease inhibitor which has been used as an anticoagulant. It also known to decrease production of inflammatory cytokines.
Products: FOY
Drug
Pramipexole
go.drugbank.com/drugs/DB00413
ApprovedInvestigational
In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS) [A176873]. … The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 [A176861].
Synonyms: (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamineProducts: Nu-pramipexole, Nb-pramipexole
Drug
Etofenamate
go.drugbank.com/drugs/DB08984
Investigational
Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).
Categories: Antiinflammatory Preparations, Non-Steroids for Topical Use, Topical Products for Joint and Muscular PainProducts: RHEUMON DEPOT IM 1 AMPUL, ETOFAST 1 G/2 ML IM ENJEKSİYONLUK ÇÖZELTI, 3 ADET
Drug
Pravastatin
go.drugbank.com/drugs/DB00175
ApprovedInvestigational
It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. … Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States.
Categories: Hypolipidemic Agents Indicated for HyperlipidemiaProducts: Nu-pravastatin Tablets, Lin-pravastatin
Drug
Alginic acid
go.drugbank.com/drugs/DB13518
ApprovedInvestigationalWithdrawn
Available in different types of salt, alginic acid has been used in a variety of uses in food, cosmetics and pharmaceu-tical products for over 100 years [A32961]. … Alginate-based raft-forming formulations in the management of heartburn and gastric acid reflux have been used worldwide for over 30 years [A32961].
Mixtures: GAVISCON INFANT ORAL COZELTI ICIN TOZ ICEREN SASE, 30 ADET, GAVISCON INFANT ORAL COZELTI ICIN TOZ ICEREN SASE, 30 ADETCategories: Compounds used in a research, industrial, or household setting, Drugs for Acid Related Disorders
Drug
Posaconazole
go.drugbank.com/drugs/DB01263
ApprovedInvestigationalVet approved
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Categories: Antimycotics for Systemic Use, Antiinfectives for Systemic UseProducts: POSIOLE® IV SOLUCIÓN PARA INFUSIÓN 300 MG/16.7 ML
Drug
Polysilicone-15
go.drugbank.com/drugs/DB11271
Approved
The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89]. … When included in various other cosmetic shampoos, conditioners, or hairsprays the compound also functions as an effective photostabilizer of the product [L2796, L2797, L2799, F87, F88, F89].
Mixtures: OHUI SUN SCIENCE Perfect Sunblock Blue EX plus
Drug
Aluminum chloride
go.drugbank.com/drugs/DB11081
ApprovedInvestigational
In antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15%, calculated on the hexahydrate form, in an aqueous solution nonaerosol dosage form [L2012]. … It may also be found in over-the-counter as an antiperspirant or prescription products as an antihemorrhagic agent.
Mixtures: Anti-perspirant Roll-ON Deod, Youth Dew Roll On Antipersp Deod LotCategories: Compounds used in a research, industrial, or household setting, Anti-Acne Preparations for Topical Use
Drug
Anakinra
go.drugbank.com/drugs/DB00026
ApprovedInvestigational
[L35415] Anakinra is indicated for the management of rheumatoid arthritis (RA) in patients 18 years of age or older who have failed one or more disease-modifying antirheumatic drugs (DMARDs), as well as … [A247265] On November 8, 2022, the FDA issued an emergency use authorization (EUA) of anakinra for the treatment of COVID-19 in hospitalized patients who are at risk of progressing to severe respiratory
Categories: Biologics for Rheumatoid Arthritis TreatmentSynonyms: IL-1RA