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Phenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnAlthough it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries.
Categories: Drugs Used in DiabetesSulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigational[A255582] Compared to the first line treatment of RA like methotrexate, sulfasalazine is almost as efficacious as methotrexate although with slightly less tolerability. … [A255582] Sulfasalazine fell out of favor as the drug of choice for RA due to poorly designed clinical trials in 1950 but regained interest from the clinical community in the late 1970.
International brands: Pyralin EN, Salazopyrin ENProducts: Azulfidine EN-tabs, SALAZOPYRIN ENPolycarbophil
go.drugbank.com/drugs/DB09311ApprovedWithdrawnIt is insoluble in water, dilute acids, and dilute alkali. … Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion.
Categories: Compounds used in a research, industrial, or household settingIndigotindisulfonic acid
go.drugbank.com/drugs/DB11577ApprovedInvestigational[A32490,A32491,A32492] In 2022, the FDA approved the intravenous use of indigotindisulfonate sodium to aid in visualizing ureter integrity in cystoscopic assessments.[L42600] … This compound is an acid-base indicator and is used in the production of food colorants and pH tests.
Categories: Compounds used in a research, industrial, or household settingSarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationalSubsequently, while a number of first line tetracycline therapies like doxycycline and minocycline do exist for treating acne vulgaris, sarecycline presents a new and innovative therapy choice because … s Seysara (sarecylcine) as a new first in class narrow spectrum tetracycline derived oral antibiotic for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients
Pegulicianine
go.drugbank.com/drugs/DB18731ApprovedInvestigationalPegulicianine is an optical imaging agent indicated for fluorescence imaging in patients with breast cancer. … [L50537] Pegulicianine (under the brand name Lumisight) was approved for use by the FDA in April 2024.[L50537,L50547] It received Fast Track and priority review for this indication.[L50547]
Categories: Compounds used in a research, industrial, or household settingBifenthrin
go.drugbank.com/drugs/DB15056ExperimentalBifenthrin is under investigation in clinical trial NCT01560247 (Percutaneous Recanalization in Ischemic Stroke Management in Europe Observational Registry).
Buspirone
go.drugbank.com/drugs/DB00490ApprovedInvestigationalIt has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate. … [A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®.
Lithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalThough it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. … Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Mixtures: BIOGROW MINProducts: Euro LithiumCalcium Phosphate
go.drugbank.com/drugs/DB11348ApprovedInvestigationalCalcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] [L851].
Categories: Compounds used in a research, industrial, or household setting