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Displaying results 151 - 160 of 134683 in total
  1. Pathway

    Diltiazem Action Pathway

    smpdb.ca/view/SMP0000359
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: ATP · Diltiazem · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  2. Pathway

    Labetalol Action Pathway

    smpdb.ca/view/SMP0000368
    Drug action

    Labetalol (also known as Albetol or Ibidomide) is an inhibitor/antagonist of beta-1 adrenergic receptor that can be used for treating high blood pressure and reducing cardiac output. … Labetalol can bind to beta-1 adrenergic receptor on both vascular smooth muscle, which lead to inhibition of vasoconstriction in peripheral blood vessels and adrenergic stimulation of endothelial cell

    Drugs: ATP · Labetalol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  3. Pathway

    Felodipine Action Pathway

    smpdb.ca/view/SMP0000377
    Drug action

    High sodium intake can contribute to hypertension. … Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK).

    Drugs: ATP · Felodipine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  4. Pathway

    Isradipine Action Pathway

    smpdb.ca/view/SMP0000378
    Drug action

    Activated myosin light chain kinase (MLCK) can phosphorylate subunit of myosin, which is an important step for muscle contraction. … Calcium ion enters the cell and bind to calmodulin, and then calcium-bound calmodulin binds and activates myosin light chain kinase (MLCK).

    Drugs: ATP · Isradipine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  5. Pathway

    Bopindolol Action Pathway

    smpdb.ca/view/SMP0000657
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Bopindolol (also known as Sandonorm) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Potassium cation · Calcium · Bopindolol
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  6. Pathway

    Sotalol Action Pathway

    smpdb.ca/view/SMP0000660
    Drug action

    Sotalol inhibits response to adrenergic stimuli by competitively blocking β1-adrenergic receptors within the myocardium and β2-adrenergic receptors within bronchial and vascular smooth muscle.

    Drugs: ATP · Sotalol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  7. Pathway

    Epinephrine Action Pathway

    smpdb.ca/view/SMP0000661
    Drug action

    Epinephrine can be derived from phenylalanine and tyrosine and it is an active sympathomimetic hormone that can be secreted from adrenal medulla. … raise up blood sugar level and breaking down lipids in adipocytes.

    Drugs: ATP · Epinephrine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  8. Pathway

    Isoprenaline Action Pathway

    smpdb.ca/view/SMP0000663
    Drug action

    Isoprenaline can bind and inhibit beta-1 adrenergic receptor on both vascular smooth muscle, which lead to inhibition of vasoconstriction in peripheral blood vessels and adrenergic stimulation of endothelial … Isoprenaline (also known as isoproterenol) is a selective beta adrenergic bronchodilator that can be used for treating slow heart rate (bradycardia), heart block, and rarely for asthma.

    Drugs: ATP · Isoprenaline · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  9. Pathway

    Arbutamine Action Pathway

    smpdb.ca/view/SMP0000664
    Drug action

    Arbutamine has nonselective beta and weak alpha-1-adrenergic activity which causes increased chronotropic activity (increase in heart rate) and inotropic activity (increase myocardial contractility). … The system monitors heart rate and blood pressure throughout infusion with alarms for physiological changes or problems.

    Drugs: ATP · Arbutamine · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  10. Pathway

    Bevantolol Action Pathway

    smpdb.ca/view/SMP0000668
    Drug action

    This results in a decrease in preload and blood pressure. … Bevantolol hydrocholride, also known as bevantolol, is a cardioselective beta blocker prescribed to treat angina pectoris and hypertension.

    Drugs: ATP · Bevantolol · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4