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Displaying results 151 - 160 of 10198 in total
  1. Drug

    Sotatercept

    go.drugbank.com/drugs/DB12118
    ApprovedInvestigational

    It is a homodimeric recombinant fusion protein consisting of the extracellular domain of the human activin receptor type IIA (ActRIIA) linked to the human IgG1 Fc domain. … [L50351] On March 26, 2024, sotatercept was approved by the FDA for the treatment of pulmonary arterial hypertension (PAH).

    Synonyms: ACTIVIN RECEPTOR TYPE IIA (SYNTHETIC HUMAN EXTRACELLULAR DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (SYNTHETIC HUMAN HEAVY CHAIN FC FRAGMENT), DIMER, (HUMAN ACTIVIN RECEPTOR TYPE-2A PRECURSOR-(21-135)-PEPTIDYL)-THREONYLTRIGLYCYL-(HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT: (8-15)-HINGE-(A-100>V)-CH2-CH3 OF HOMO SAPIENS IGHG1*03), (123-
  2. Drug

    Adapalene

    go.drugbank.com/drugs/DB00210
    ApprovedInvestigational

    to treat mild-to-severe acne. … Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum.

    Mixtures: Clindap-TProducts: T3 Ada Gel 0.1%
  3. Drug

    Pyrithione

    go.drugbank.com/drugs/DB06815
    ApprovedInvestigational

    It is not shown to have any significant estrogenic activity according to the _in vivo_ and _in vitro_ assays [A32163]. … Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces [A27133].

    Mixtures: Neutrogena T/Gel TherapeuticProducts: Derma Doctor Born to be Mild Cleanser, T/gel Daily Control
  4. Drug

    Benzoyl peroxide

    go.drugbank.com/drugs/DB09096
    ApprovedInvestigational

    [L33314] After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.

    Mixtures: Clear Proof Acne System The Go Set, Clenziderm Normal To Oily Skin Acne Therapeutic SystemSynonyms: Peróxido de benzoilo
  5. Drug

    Nemolizumab

    go.drugbank.com/drugs/DB15252
    ApprovedInvestigational

    [A264254] By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation. … Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology

    Categories: Interleukin-31 Receptor alpha AntagonistSynonyms: Immunoglobulin G2, anti-(interleukin 31 receptor A) (human-Mus musculus monoclonal CIM331 γ-chain), disulfide with human-Mus musculus monoclonal CIM331 κ-chain, dimer, immunoglobulin G2-kappa, anti-[Homo sapiens IL31RA (interleukin 31 receptor subunit alpha)], humanized monoclonal antibody gamma2 heavy chain (1-445) [humanized VH (Homo sapiens IGHV1-2*02 (83.70%) -(IGHD
  6. Drug

    RTL-1000

    go.drugbank.com/drugs/DB17946
    Investigational

    RTL-1000 is a recombinant T-Cell receptor ligand being investigated for the treatment of multiple sclerosis.

    Synonyms: Recombinant t-cell receptor ligand rtl-1000, Rtl-1000 (recombinant t-cell receptor ligand)
  7. Drug

    Diphenhydramine

    go.drugbank.com/drugs/DB01075
    ApprovedInvestigational

    Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, … As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the

    Mixtures: ZoDen PD, LAPISIV-TProducts: On The GO-Dose, The Itch Eraser
  8. Drug

    Sipavibart

    go.drugbank.com/drugs/DB21908
    ApprovedInvestigational

    [A274098] It works by binding to the SARS-CoV-2 spike protein receptor binding domain (RBD), neutralize the virus and preventing its entry into the host cell. … [A274088] Sipavibart is approved for the pre-exposure prophylaxis treatment of COVID-19 in immunocompromised patients.[L53418]

    Synonyms: Gamma1 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-9*01 (94.9%) -(IGHD) -IGHJ1*01 (90.9%) L123>T (120), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125) -Homo sapiens IGHG1*03, G1m3, nG1m1, Immunoglobulin G1-lambda, anti-[Homo sapiens severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody
  9. Drug

    Tividenofusp alfa

    go.drugbank.com/drugs/DB17628
    ApprovedInvestigational

    Tividenofusp alfa is a recombinant human IDS fused to a monoclonal antibody that targets the human insulin receptor (HIR), utilizing receptor-mediated transcytosis to gain access to the central nervous … While standard ERTs can treat systemic symptoms, they are unable to cross the blood-brain barrier (BBB) to address the progressive cognitive decline and neurological impairment seen in the majority of

    Synonyms: ENZYME TRANSPORT VEHICLE SPECIFIC FOR THE TRANSFERRIN RECEPTOR FUSED TO IDURONATE 2-SULFATASE, - L-iduronate sulfate sulfatase, EC:3.1.6.13) pro-protein (1-525), fused via the peptide linker 526 GGGGS 530 to a human immunoglobulin G1 C-terminal Fc fragment (531-757) variant (L 544>A, L 545>A, T
  10. Drug

    Synthetic camphor

    go.drugbank.com/drugs/DB14156
    Approved

    Mixtures: Huo Pao Tieh Ta Feng Shin Kao, Wong To Yick External AnalgesicProducts: CBD Clinic - Mild To Moderate Muscle and Joint Pain Relief, De La Cruz Camphor