Identification
- Summary
Pyrithione is an antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.
- Brand Names
- Biokera
- Generic Name
- Pyrithione
- DrugBank Accession Number
- DB06815
- Background
Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat dandruff and seborrheic dermatitis. Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as Malassezia globosa and M. restricta 3.
Pyrithione zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth 1. Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces 2. Other uses of pyrithione zinc include additive in antifouling outdoor paints and algaecide. While its use has been approved in the early 1960's by the FDA 4, safety and effectiveness of pyrithione zinc has been reported for decades. It is not shown to have any significant estrogenic activity according to the in vivo and in vitro assays 4.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Pyrithione (DB06815)
- Weight
- Average: 127.16
Monoisotopic: 127.009184959 - Chemical Formula
- C5H5NOS
- Synonyms
- 2-pyridinethiol 1-oxide
- Omadine
- Pyridinethiol N-oxide
- External IDs
- NSC-290409
Pharmacology
- Indication
Indicated for the treatment of dandruff and seborrheic dermatitis 2.
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- Contraindications & Blackbox Warnings
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Pyrithione zinc has a broad antimicrobial spectrum of activity, including fungi, gram-positive and gram-negative bacteria 2. Pyrithione zinc is effective against Malassezia and all other fungi, especially the Malassezia species found on scalp 5. In patients with dandruff, treatment with pyrithione zinc reduced the amount of fungus on the scalp, which reduces the amount of free fatty acids, thereby reducing scalp flaking and itch 5.
- Mechanism of action
Inhibition of fungal growth by pyrithione zinc is linked to increased copper uptake and cellular levels of copper, which is demonstrated by decreased CTR1-lacZ expression and slightly increased CUP1-lacZ expression in affected microorganisms 3. The coordination complex of pyrithione zinc dissociates, and pyrithione ligand forms a CuPT complex from available extracellular copper in the target organism. Pyrithione acts as an ionophore, interacting nonspecifically with the plasma membrane to shuttle copper into the cell, and facilitates copper transport across intracellular membranes 3. Copper may be shuttled into the mitochondria. Copper inactivates iron-sulfur (Fe-S) cluster-containing proteins via a mechanism similar to that described for copper-induced growth inhibition in bacteria 3. Decreased activity of Fe-S proteins leads to inhibition of fungal metabolism and fungal growth. Pyrithione zinc has been shown to slightly increase the levels of zinc 3.
- Absorption
Following oral ingestion, only the pyrithione moiety is absorbed. Less than 1% of administered zinc pyrithione is absorbed from the skin 6. Radioabeled Zn pyrithione administered to rats, rabbits and monkeys, either orally or via intraperitoneal injection were absorbed into circulatin to extent of 80-90% 6.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
After oral administration in rabbits, rats, monkeys, and dogs, pyrithione zinc is biotransformed into 2-pyridinethiol 1-oxide S-glucuronide and 2-pyridinethiol S-glucuronide 6.
- Route of elimination
The major route of elimination from the body after oral administration in rat was urine, with S-glucuronides of 2-mercaptopyridine-N-oxide being the major metabolites and 2-mercaptopyridine-N-oxide as the minor metabolite. Following oral administration, the majority of zinc is eliminated in the feces 6. Upon dermal administration, >90% of recovery was obtained from washings of the application site of pigs. Urinary excretion was 3% in animals with intact skin 6.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Acute oral LD50 value is 177 mg/kg in rat and 160 mg/kg in mouse. Acute dermal LD50 was 100 mg/kg in rabbit MSDS.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareTenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Pyrithione. 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Pyrithione sodium 6L3991491R 3811-73-2 WNGMMIYXPIAYOB-UHFFFAOYSA-M Pyrithione zinc R953O2RHZ5 13463-41-7 OTPSWLRZXRHDNX-UHFFFAOYSA-L - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 2 In 1 Shampoo 10.4 mg/1mL Topical TARGET Corporation 2013-05-16 Not applicable US 
2 In 1 Shampoo 10.3 mg/1mL Topical TARGET Corporation 2013-05-06 Not applicable US 2 In 1 Shampoo 10.3 mg/1mL Topical Wal-Mart Stores, Inc 2012-07-12 Not applicable US 2 In 1 Shampoo 10 mg/1mL Topical Lidl Us Llc 2021-08-12 Not applicable US 2 in 1 anti-Dandruff Shampoo 10 mg/1mL Topical Spa Dent Inc 2021-07-20 Not applicable US 2 In 1 Anti-dandruff Shampoo and Conditioner Lotion 1 % Topical Avon Products, Inc. 2003-10-09 2010-07-30 Canada 
2 in 1 Antidandruff Shampoo 10 mg/1mL Topical Apollo Health and Beauty Care Inc. 2017-03-29 Not applicable US 2 In 1 Conditioning Dandruff Shampoo Shampoo 1 % Topical Scott Chemical Canada 2000-01-01 2005-09-16 Canada 2 In 1 Conditioning Dandruff Treatment Shampoo Shampoo 1 % Topical Apollo Health and Beauty Care Inc. 2002-10-30 2011-07-07 Canada 2 in 1 Dandruff Shampoo 10 mg/1mL Topical Vi-Jon, LLC 2005-06-23 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 574H Cell Care Pyrithione zinc (3.0 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Panthenol (1.5 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US Actiprep Pyrithione zinc (1 %) + Ethanol (83 %) Liquid Topical Healthpoint 2002-09-12 2004-07-13 Canada Add More Hair Pyrithione zinc (0.29 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2017-03-01 2018-09-04 US Add More Hair Pyrithione zinc (0.28 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US Anti Hair Loss Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) Soap Topical Golden B America, Llc. 2018-03-13 Not applicable US Antibacterial Hand Sanitizer Pyrithione zinc (0.15 1/1001) + Sodium chloride (0.8 1/1001) + Sodium hydroxide (0.03 1/1001) Liquid Topical SHANTOU WBM TRADING CO., LTD. 2020-03-19 Not applicable US Antibacterial Hand Sanitizer Pyrithione zinc (0.15 1/1001) + Sodium chloride (0.8 1/1001) + Sodium hydroxide (0.03 1/1001) Liquid Topical SHANTOU WBM TRADING CO., LTD. 2020-03-19 Not applicable US Bonnoir Hair Medi Pyrithione zinc (7.35 mL/350mL) + Biotin (0.21 mL/350mL) + Nicotinamide (1.05 mL/350mL) + Panthenol (1.75 mL/350mL) Shampoo Topical Cellinbio Co Ltd 2011-07-27 Not applicable US Bonogen hair care shampoo Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.5 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US Bonogen Plus hair care shampoo Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 574H Cell Care Pyrithione zinc (3.0 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Panthenol (1.5 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US Add More Hair Pyrithione zinc (0.28 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US Add More Hair Pyrithione zinc (0.29 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2017-03-01 2018-09-04 US Anti Hair Loss Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) Soap Topical Golden B America, Llc. 2018-03-13 Not applicable US Bonnoir Hair Medi Pyrithione zinc (7.35 mL/350mL) + Biotin (0.21 mL/350mL) + Nicotinamide (1.05 mL/350mL) + Panthenol (1.75 mL/350mL) Shampoo Topical Cellinbio Co Ltd 2011-07-27 Not applicable US Bonogen hair care shampoo Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.5 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US Bonogen Plus hair care shampoo Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US Born Hair Pyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US Carione Rg Pyrithione zinc (2.1 g/100mL) + Biotin (0.06 g/100mL) + Nicotinamide (0.3 g/100mL) + Panthenol (0.5 g/100mL) Shampoo Topical Cell Activation Research Institute Co., Ltd 2016-07-31 Not applicable US Doll Lash Pyrithione zinc (2 mL/100mL) + Biotin (0.06 mL/100mL) + Nicotinamide (0.3 mL/100mL) + Panthenol (0.5 mL/100mL) Liquid Topical Hanbit Korea 2010-11-06 Not applicable US
Categories
- ATC Codes
- D11AX12 — Pyrithione zinc
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Yeast and other fungi
Chemical Identifiers
- UNII
- 6GK82EC25D
- CAS number
- 1121-31-9
- InChI Key
- FGVVTMRZYROCTH-UHFFFAOYSA-N
- InChI
- InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
- IUPAC Name
- 2-sulfanylpyridin-1-ium-1-olate
- SMILES
- [O-][N+]1=C(S)C=CC=C1
References
- Synthesis Reference
Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4.
- General References
- Reeder NL, Xu J, Youngquist RS, Schwartz JR, Rust RC, Saunders CW: The antifungal mechanism of action of zinc pyrithione. Br J Dermatol. 2011 Oct;165 Suppl 2:9-12. doi: 10.1111/j.1365-2133.2011.10571.x. [Article]
- Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4. [Article]
- Reeder NL, Kaplan J, Xu J, Youngquist RS, Wallace J, Hu P, Juhlin KD, Schwartz JR, Grant RA, Fieno A, Nemeth S, Reichling T, Tiesman JP, Mills T, Steinke M, Wang SL, Saunders CW: Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother. 2011 Dec;55(12):5753-60. doi: 10.1128/AAC.00724-11. Epub 2011 Sep 26. [Article]
- Yoon KS, Youn N, Gu H, Kwack SJ: Estrogenic activity of zinc pyrithione: an in vivo and in vitro study. Environ Health Toxicol. 2017 Feb 9;32:e2017004. doi: 10.5620/eht.e2017004. eCollection 2017. [Article]
- DeAngelis YM, Gemmer CM, Kaczvinsky JR, Kenneally DC, Schwartz JR, Dawson TL Jr: Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity. J Investig Dermatol Symp Proc. 2005 Dec;10(3):295-7. doi: 10.1111/j.1087-0024.2005.10119.x. [Article]
- Pyrithione zinc - National Library of Medicine HSDB Database - Toxnet [Link]
- NPRA Product Information: Dezor Plus (zinc pyrithione/ketoconazole) topical shampoo [Link]
- External Links
- PubChem Compound
- 26041
- PubChem Substance
- 347827800
- ChemSpider
- 10446934
- BindingDB
- 50366038
- 35100
- ChEBI
- 36584
- ChEMBL
- CHEMBL1356238
- ZINC
- ZINC000000156822
- Wikipedia
- Pyrithione_zinc
- MSDS
- Download (57 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Hyperpigmentation 1 4 Recruiting Treatment Atopic Dermatitis 1 4 Unknown Status Treatment Quality of Life (QOL) / Seborrheic Dermatitis 1 3 Terminated Treatment Atrophic Vaginitis 1 0 Completed Basic Science Rosacea 1 Not Available Completed Treatment Fungal Infection in Perineal Area / Moisture-associated Dermatitis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Shampoo Topical 10.3 mg/1mL Shampoo Topical 1.2 % Lotion Topical 0.1 % w/w Lotion Topical 0.15 mL/150mL Shampoo Topical 0.15 g/1mL Soap Topical 2 g/1000g Lotion Topical 2.1 g/100mL Solution Topical 20 mg/1mL Shampoo Cutaneous 0.01 mg/1mL Shampoo Cutaneous 10 mg/1mL Soap Topical Shampoo Topical 0.05 g/100g Shampoo Topical 10 mg/100mL Shampoo Topical 2.0 % Shampoo Topical 1 % w/v Shampoo Topical 10 mg/1000mg Shampoo Topical 20 mg/1mL Emulsion Topical 10 mg/1g Shampoo Topical 10 mg/1mL Lotion Topical 2.14 mg/1mL Shampoo Topical 2.14 mg/1mL Shampoo Topical 10.32 mg/1mL Cream Topical 2.14 mg/1mL Liquid Topical 0.2 % Shampoo Topical 10.2 mg/1mL Liquid Topical 10.2 mg/1mL Liquid Topical 4.9 mg/1mL Cream Topical 0.2 g/100g Liquid; shampoo Topical 1 % Shampoo Topical 2.3 g/230g Shampoo Topical 1.05 g/100mL Lotion / shampoo Topical .1 g/10g Lotion / shampoo Topical .5 g/10g Lotion / shampoo Topical 1 g/10g Shampoo Topical 4.5 mL/300mL Spray Topical 0.19 mg/1mL Cream Topical 0.2 mg/1g Cream Topical 0.2 mg/1mL Shampoo Topical Cream Topical .1 % Gel Topical 0.95 g/100mL Shampoo Topical 5.7 g/285mL Shampoo Topical 5.8 mg/290mL Gel Topical 0.1 % Suspension Topical 0.5 g/100mL Shampoo Topical 1.0 g/100mL Solution Topical 0.1 % w/w Shampoo, suspension Topical 20 mg/1mL Shampoo Topical 0.5 g/100mL Lotion Topical 0.0036 mg/1mL Liquid Topical 15 g/300mL Kit; shampoo; soap Topical Shampoo Topical 0.003 g/1mL Shampoo Cutaneous 3 g/300g Shampoo Topical 2 % Lotion Topical 10 mg/1g Shampoo Topical 20 mg/1g Shampoo Topical 1 kg/100L Shampoo Topical 1 mg/1mL Shampoo Topical 1.0 % w/w Shampoo Topical 1.9 g/100mL Shampoo Topical 10.0 mg/100mL Shampoo Topical 10.4 mg/1mL Shampoo Topical 100 g/1mL Shampoo, suspension Topical 958 mg/1mL Lotion / shampoo Topical 1.0000 mL/100mL Suspension Topical 0.5 % w/w Lotion / shampoo Topical 0.500 mL/100mL Cream Topical 1 % w/w Cream Topical 1 % Shampoo Topical 1.45 % Lotion / shampoo Topical 1 kg/100L Suspension Topical 1 % Lotion Topical 1 % w/w Lotion Topical 1.0 % w/w Suspension Topical 1.0 % Gel Topical 2.0 g/100mL Soap Topical 1 g/100g Cream Topical 0.25 g/100mL Cream Topical 0.25 g/100g Spray Topical 0.25 g/100mL Cream Topical 2.5 mg / g Shampoo Topical 20 mg / g Spray Topical 0.25 % Shampoo Topical 1.65 g/100ml Solution Topical 0.95 g/100g Liquid Topical Cream Topical 1 mg/1mL Liquid Topical 0.5 g/100mL Shampoo Topical 2.4 g/500g Shampoo Topical 14 mg/1mL Shampoo Topical 1.2 g/100g Shampoo Topical 12 g/1L Solution Topical 2.4 mg/500mL Solution Topical 0.09 g/100mL Shampoo Topical 1.2 g/100mL Shampoo Topical 10 mL/1000mL Shampoo Topical 65.7 g/1000mL Shampoo Topical 300 mg/100mL Liquid Topical 3 mg/1mL Liquid Topical 0.05 g/1mL Shampoo Topical 5.28 mg/1mL Liquid Topical 0.0036 mg/1mL Liquid Topical 0.00528 g/1mL Liquid Topical 0.011 mg/1mL Liquid Topical 0.0034 mg/1mL Shampoo Topical 1.0 g / 100 g Shampoo Topical 10 mg/10mL Shampoo Topical 1 g/100mL Lotion / shampoo Topical 0.02 kg/1kg Shampoo Topical 0.000048 g/100mL Shampoo Topical 1.008 g/100mL Shampoo Topical 1.8 mg/300mL Shampoo Topical 2 g/100mL Shampoo Topical 1 kg/100kg Shampoo Topical 12 mg/1mL Shampoo Topical 2.5 g/250g Lotion Topical 1 % Shampoo Topical 1.68 % Shampoo Topical 6 mg/300mL Shampoo Topical 6.4 g/320mL Shampoo Topical 0.1 mL/100mL Solution Topical 0.1 mL/100mL Shampoo Topical 0.0095 g/1mL Shampoo Topical 0.75 % w/w Shampoo Topical 0.5 % Shampoo Topical 0.5 % w/w Cream Topical 0.75 % w/w Lotion / shampoo Topical 0.01 mg/1mg Lotion / shampoo Topical 10 mg/1mL Lotion Topical 0.75 g/100mL Cream Topical 0.2 g/100mL Lotion Topical 0.2 g/100mL Liquid Topical 0.1 g/100mL Lotion / shampoo Topical 0.5 g/1mL Lotion Topical 0.5 g/100mL Lotion Topical 5 mg/1mL Kit; lotion; shampoo Topical Kit; lotion; lotion / shampoo Topical Lotion / shampoo Topical 2 g/100mL Lotion / shampoo Topical 20 mg/1mL Paste Topical 0.1 g/100g Lotion / shampoo Topical 1 g/1mL Shampoo Topical 0.01 g/1mL Lotion Topical 0.5 mg/100mL Lotion / shampoo Topical 1 g/100mL Lotion / shampoo Topical .01 g/1mL Lotion / shampoo Topical 0.01 g/1mL Cream Topical 0.1 g/100mL Cream Topical 0.5 g/100mL Lotion Topical 0.1 g/100g Lotion Topical 0.1 g/100mL Lotion Topical 1 g/100mL Cream Topical 0.1 g/100g Gel Topical 0.1 g/100mL Cream Topical 1 g/100mL Lotion / shampoo Topical 7.5 mg/1mL Shampoo Topical 1.5 g/100g Shampoo Topical 15 mg/1mL Emulsion Topical 1.0 g/100g Shampoo Topical 15.4 g/1L Shampoo Topical 0.1 % w/w Shampoo Topical 1.1 g/100g Shampoo Topical 1.0 g/100g Shampoo Topical 1.8 % Liquid Topical 1 g/100mL Lotion Topical 2 mg/1mL Shampoo Topical 1.5 % Liquid Topical 2.1 g/100mL Shampoo Topical 0.00336 g/1mL Shampoo Topical 1 % Shampoo Topical 0.3 mg/100mL Shampoo Topical 0.3 g/100mL Shampoo Topical .01 g/1g Shampoo, suspension Topical .01 g/1g Shampoo Topical 1.8 g/100mL Shampoo Topical 15.0 g/1.0L Shampoo Topical 3.0 g/300g Shampoo Topical 1.008 g / 100 g Lotion Topical 10 mg/1mL Shampoo Topical 1.20000 mg/240mL Shampoo Topical 10.5 mg/1mL Shampoo Topical 2.52000 mg/240mL Shampoo Topical 1 g/100g Shampoo Topical 0.2 % w/w Shampoo Topical 10.0 g/500mL Shampoo Topical 1.5 g/500mL Gel Topical 0.48 g/100mL Kit Topical Lotion / shampoo Topical 1 mg/1mL Liquid Topical 0.97 mg/1mL Lotion / shampoo Topical 0.1 g/100mL Solution Topical 0.1 % Cream Topical 1 mL/100mL Shampoo Topical 1 g/1mL Liquid Topical 20 mg/1mL Liquid Topical 1 % Liquid Topical 1.0 % Gel Topical 2.0 g/100g Shampoo Topical 4.04 g/400mL Shampoo, suspension Topical 1 g/100mL Shampoo, suspension Topical 0.45 mL/100mL Shampoo, suspension Topical 1 mL/100mL Lotion Topical 0.5 % w/w Shampoo Topical 1 mg/100mL Cream Topical 3 mg/1000mL Liquid Topical 29 mg/1mL Shampoo Topical 2.41 g/237mL Gel Topical 1 % w/w Shampoo Topical 1.0 % Shampoo Cutaneous 0.6 mL/360mL Shampoo Topical 2.1 g/100mL Shampoo Topical 1 mL/100mL Liquid Topical 10 mg/1mL Liquid Topical 1 mL/100mL Liquid Topical 1.0 mL/100mL Cream Topical 9.5 mg/1mL Shampoo Topical 0.95 % Shampoo Topical 1.9 % Shampoo Topical 0.95 % w/w Shampoo Topical 9.5 mg/1mL Shampoo Topical 5.0 g/500mL Shampoo Topical 1 % w/w Shampoo Topical 5 g/250g Shampoo Topical 10 mg/1g Shampoo Topical 3 mg/300mL Solution Topical 0.95 g/100mL Aerosol Topical 2 mg / mL Shampoo Topical 0.3 % w/w Shampoo Topical 6 mg/1mL Shampoo Topical 1 g / 100 g Suspension Topical 0.25 % Shampoo Topical 0.5 mL/100mL Shampoo Topical 1.0 mL/100mL Suspension Topical 0.5 mL/100mL Cream Topical 1 mg/1g Shampoo, suspension Topical 10 mg/1mL Lotion Topical 1 mg/1mL Cream Topical 0.1 % w/w Lotion / shampoo Topical 1.2 g/1mL Shampoo Topical .01 g/.01g Rinse Topical .005 g/1g Rinse Topical 1 g/100mL Rinse Topical 5 mg/1mL Cream Topical 0.125 g/100mL Lotion Topical Shampoo Topical 10 g / kg Shampoo Topical 2 % w/w Soap Topical 2 g/100g Shampoo Topical 5 g/500g Cream Topical 250 mg/100g Liquid Topical .15 % Lotion / shampoo Topical 300 mg/100mL Liquid Topical 5 g/1000mL Shampoo Topical 2 g/100g Lotion / shampoo Topical 20 mg/400mg Shampoo Topical 20 mg/400mg Shampoo Topical 2.98 g/300mL Suspension Topical 2 % Gel Topical 1 g/100g Shampoo Topical 20 mg/2mL Liquid Topical 2 g/100mL Cream Topical 0.2 % Spray Topical 0.2 % Suspension Topical 100 g Soap Topical 0.020 g/1 Soap Topical 2 % Cream Topical .5 % - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source boiling point (°C) 100 (Zinc salt) MSDS water solubility Soluble in cold water (Zinc salt) MSDS - Predicted Properties
Property Value Source Water Solubility 3.0 mg/mL ALOGPS logP 0.87 ALOGPS logP 0.2 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 6.84 Chemaxon pKa (Strongest Basic) 0.66 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 26.94 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 34.48 m3·mol-1 Chemaxon Polarizability 12.19 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at September 14, 2010 16:21 / Updated at March 25, 2023 04:38