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Rimonabant

It was rejected for approval for use in the United States. … It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite.

Arimoclomol

[L51384] Arimoclomol was approved by the FDA on September 20, 2024, making it the first treatment for Niemann-Pick disease, type C (NPC).

Thiram

Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada [L5425].

Bromfenac

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. … Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes.

Conjugated estrogens

[T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions. … However, until 1986 official clinical trials were performed and this product was determined to be effective for the treatment of osteoporosis.

Nonoxynol-9

N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants.

Streptococcus pneumoniae type 6a capsular polysaccharide antigen

Icotrokinra

It was jointly discovered and developed by Protagonist and Johnson & Johnson[L56118] and provides a novel, oral treatment option for patients requiring systemic therapy for plaque psoriasis. … [L56108,L56118] Icotrokinra was approved by the US FDA in March 2026 for the systemic treatment of moderate-to-severe plaque psoriasis.[L56108]

Influenza B virus B/Maryland/15/2016 antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposin...

Sodium phosphate, dibasic