Search
Ecallantide
go.drugbank.com/drugs/DB05311ApprovedApart from its FDA and EMA indication, ecallantide has been used off label in the management of nonhistaminergic angioedema, not due to HAE [A32017]. … Hereditary angioedema is a rare autosomal dominant disorder with mutations to C1-esterase-inhibitor (C1-INH) located on Chromosome 11q, resulting in substantially lower levels of C4 and C1-INH activity
Categories: Analgesics, Non-Narcotic, Drugs Used in Hereditary AngioedemaIdursulfase
go.drugbank.com/drugs/DB01271ApprovedInvestigationalThe enzyme activity of idursulfase is dependent on the post-translational modification of a specific cysteine to formylglycine. … Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various cell types
Etranacogene dezaparvovec
go.drugbank.com/drugs/DB16791ApprovedInvestigationaldue to the requirement of routine intravenous infusions. … [L44161] Men are most likely to experience symptomatic illness due to the X-linked provenance of the disorder.
Mafenide
go.drugbank.com/drugs/DB06795ApprovedVet approvedWithdrawnIn November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
Categories: combinations of sulfonamidesFlavin mononucleotide
go.drugbank.com/drugs/DB03247ApprovedInvestigational[L54226] In addition to its systemic use as a means of riboflavin supplementation, a topical ophthalmic preparation of FMN was approved by the FDA in October 2025 for use as a photoenhancer in epithelium-on … Flavin mononucleotide (FMN), also known as riboflavin 5'-phosphate, is one of the two major coenzymes derived from [riboflavin] (vitamin B2) and is one of the principal forms in which dietary riboflavin
Mixtures: Soluvit N, Soluvit NLonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[L23414, L23544] Lonafarnib was granted FDA approval on November 20, 2020, and is the first FDA-approved treatment for HGPS and other related progeroid laminopathies.[L23414, L23549] … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.
Fenofibrate
go.drugbank.com/drugs/DB01039ApprovedInvestigational[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993.[L8585]
Categories: Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaProducts: Nu-feno-microClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: Drugs for Treatment of LepraPlicamycin
go.drugbank.com/drugs/DB06810ApprovedWithdrawnIt has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. … Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus.
Categories: Compounds used in a research, industrial, or household settingClodronic acid
go.drugbank.com/drugs/DB00720ApprovedInvestigationalVet approved[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. … [A1923] clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]
Categories: Drugs for Treatment of Bone Diseases