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Displaying results 1611 - 1620 of 8696 in total
  1. Target

    GABA(B) Receptor

    go.drugbank.com/bio_entities/BE0010194
    Target

    Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating … Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 1, GABA-B receptor 2
  2. Target

    Interleukin-21 receptor

    go.drugbank.com/bio_entities/BE0010657
    TargetHumans

    This is a receptor for interleukin-21

    Polypeptides: Interleukin-21 receptorSynonyms: IL-21 receptor, Novel interleukin receptor
  3. Target

    Neuromedin-B receptor

    go.drugbank.com/bio_entities/BE0013104
    TargetHumans

    Receptor for neuromedin-B (PubMed:1655761). … Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)

    Polypeptides: Neuromedin-B receptorSynonyms: Neuromedin-B-preferring bombesin receptor
  4. Target

    Interleukin-23 receptor

    go.drugbank.com/bio_entities/BE0015564
    TargetHumans

    Associates with IL12RB1 to form the interleukin-23 receptor. … IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis

    Polypeptides: Interleukin-23 receptorSynonyms: IL-23 receptor
  5. Target

    Discoidin domain receptor

    go.drugbank.com/bio_entities/BE0027487
    TargetHumans

    Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. … It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.

    Polypeptides: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin domain receptor 2, Discoidin receptor tyrosine kinase
  6. Target

    Interleukin-2 receptor

    go.drugbank.com/bio_entities/BE0027978
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit gamma, IL-2 receptor subunit alpha
  7. Drug

    Cannabidiol

    go.drugbank.com/drugs/DB09061
    ApprovedInvestigational

    Although THC and CBD have been the most studied cannabinoids, there are many others identified to date including cannabinol (CBN), cannabigerol (CBG), [DB14050] (CBDV), and [DB11755] (THCV) that can be … Through its modulation of neurotransmitter release, the endocannabinoid system regulates cognition, pain sensation, appetite, memory, sleep, immune function, and mood among many other bodily systems.

    Categories: Serotonin Receptor Agonists, Serotonin 5-HT1 Receptor AgonistsSynonyms: (−)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol
  8. Indication

    Status Epilepticus

    go.drugbank.com/conditions/DBCOND0028922
    Drugs: Clobazam · Diazepam · Felbamate · Fosphenytoin · Lacosamide · Lorazepam +1 more
    Synonyms: Grand mal status, Grand mal status, epileptic
  9. Drug

    Phentermine

    go.drugbank.com/drugs/DB00191
    ApprovedIllicitInvestigational

    [A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. … [A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.

    Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 SubstratesProducts: Adipex-P
  10. Drug

    Sulbactam

    go.drugbank.com/drugs/DB09324
    ApprovedInvestigational

    [L50131] When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.[A263296]

    Mixtures: SULBACTER POWDER FOR SOLUTION FOR INJECTION or INFUSION 3g/vial, SULBACTER POWDER FOR SOLUTION FOR INJECTION or INFUSION 1.5g/vialCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use