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Displaying results 1611 - 1620 of 1640 in total
  1. Drug

    Human Umbilical Cord Mesenchymal Stem Cells

    go.drugbank.com/drugs/DB15726
    Investigational

    umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marrow derived stem cells (they can maintain a steady doubling time (DT) over

  2. Drug

    Paritaprevir

    go.drugbank.com/drugs/DB09297
    ApprovedInvestigational

    Lack of significant side effects and short duration of therapy is a considerable advantage over older interferon-based regimens, which were limited by infusion site reactions, reduced blood count, and

  3. Drug

    Buprenorphine

    go.drugbank.com/drugs/DB00921
    ApprovedIllicitInvestigationalVet approved

    Buprenorphine may also be a preferred agent over [methadone] (which is also commonly used to treat severe pain and opioid use disorder), as it has less effect on Qtc interval prolongation,[A186271,A186274 … Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.

  4. Target

    Cytohesin-3

    go.drugbank.com/bio_entities/BE0004433
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)

    Synonyms: General receptor of phosphoinositides 1
  5. Target

    Elongation factor 1-alpha 1

    go.drugbank.com/bio_entities/BE0004528
    TargetHumans

    Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:362...

    Synonyms: Leukocyte receptor cluster member 7
  6. Target

    C-type lectin domain family 7 member A

    go.drugbank.com/bio_entities/BE0019143
    TargetHumans

    Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed

    Synonyms: Beta-glucan receptor
  7. Target

    COUP transcription factor 1

    go.drugbank.com/bio_entities/BE0008953
    TargetHumans

    Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of th...

    Synonyms: Nuclear receptor subfamily 2 group F member 1
  8. Target

    Retinoic acid-induced protein 3

    go.drugbank.com/bio_entities/BE0000697
    TargetHumans

    Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells.

    Synonyms: G protein-coupled receptor family C group 5 member A
  9. Target

    VLA-4 (very late antigen-4)

    go.drugbank.com/bio_entities/BE0010014
    TargetHumans

    Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. … Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.

    Synonyms: Fibronectin receptor subunit beta
  10. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...

    Synonyms: Angiotensin/vasopressin receptor AII/AVP-like