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Displaying results 1611 - 1620 of 10000 in total

Drug
Amedalin
go.drugbank.com/drugs/DB09188
Experimental
Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s.
Synonyms: 3-methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinone
Drug
Lobeglitazone
go.drugbank.com/drugs/DB09198
Investigational
Unlike [DB01132], which is a dual PPAR agonist at PPAR-alpha and PPAR-gamma, Lobeglitazone is a pure PPAR-alpha agonist. … Lobeglitazone is an antidiabetic medication from the thiazolidinedione class of drugs.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Ciglitazone
go.drugbank.com/drugs/DB09201
Experimental
Ciglitazone is a potent and selective PPARγ ligand with an EC50 of 3.0 µM. It is also an anti-hyperglycemic agent in the ob/ob murine model in vivo. … Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
Drug
AS-8112
go.drugbank.com/drugs/DB09207
Experimental
AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.
Categories: Heterocyclic Compounds, 1-Ring
Drug
Droxicam
go.drugbank.com/drugs/DB09215
ApprovedWithdrawn
Droxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554]. … It is used to reduce pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring
Drug
Tolfenamic acid
go.drugbank.com/drugs/DB09216
Approved
Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. … It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSProducts: TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS, Tolfine Solution for Injection 4.0% W/V
Drug
Nicorandil
go.drugbank.com/drugs/DB09220
ApprovedInvestigationalWithdrawn
It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium channels. … Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular
Categories: Heterocyclic Compounds, 1-RingSynonyms: N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)
Drug
Blonanserin
go.drugbank.com/drugs/DB09223
Investigational
It offers improved tolerability as it lacks side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. … As a second-generation (atypical) antipsychotic, it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
Drug
Melperone
go.drugbank.com/drugs/DB09224
Investigational
Recently, it has been studied as a treatment of psychosis related to Parkinson's disease [L1316]. … It has been well established in the treatment of confusion, anxiety, restlessness (particularly in the elderly) and schizophrenia as It is known to be well-tolerated with an excellent safety profile.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Cilnidipine
go.drugbank.com/drugs/DB09232
Investigational
Cilnidipine is a dihydropyridine calcium antagonist. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved in 1995. … Compared with other calcium antagonists, cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring