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Metaxalone
go.drugbank.com/drugs/DB00660ApprovedInvestigationalIts main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet. … Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTrichlormethiazide
go.drugbank.com/drugs/DB01021ApprovedVet approvedA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Categories: combinations of sulfonamidesIvacaftor
go.drugbank.com/drugs/DB08820ApprovedInvestigational[A20302] Prior to the development of ivacaftor, management of CF primarily involved therapies for the control of infections, nutritional support, clearance of mucus, and management of symptoms rather … Notably, ivacaftor was the first medication approved for the management of the underlying causes of CF (abnormalities in CFTR protein function) rather than control of symptoms.[A20297]
Pholcodine
go.drugbank.com/drugs/DB09209ApprovedIllicit[A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative effect with little or no analgesic effects. … It belongs to the opioid family of compounds and it is widely used.
Categories: Heterocyclic Compounds with 4 or More RingsProducts: DHACODINE SYRUP 15 mg/5 ml, DURO-TUSS FORTE COUGH LIQUID 45 mg/15 mlOxolamine
go.drugbank.com/drugs/DB13216ApprovedOxolamine is also approved in Taiwan for the treatment of respiratory tract inflamation [L5422].
Mixtures: KATARİN 250 MG/100 MG/2 MG KAPSÜL, 15 ADET, KATARIN FORT 650 MG/200 MG/60 MG/4 MG FİLM KAPLI TABLET, 20 ADETProducts: BRONKO 1200 MG 120 ML SURUP, OXOTUSS ŞURUP 50 MG/5 ML, 120 MLMercaptopurine
go.drugbank.com/drugs/DB01033ApprovedInvestigationalIt interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Categories: combinations of xanthinesProducts: PURINETHOL50 MG, EMPURINE 50 MGSibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIn October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease. … Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity.
Categories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: SINHABIT 10 MG, SINHABIT 15 MGRisdiplam
go.drugbank.com/drugs/DB15305ApprovedInvestigationalseverity or type. … This mechanism of action is similar to its predecessor [nusinersen], the biggest difference being their route of administration: nusinersen requires intrathecal administration, as does the one-time gene
Categories: Survival of Motor Neuron 2 Splicing ModifierProducts: Evrysdi Powder for oral solution 0.75 mg/mL, EVRYSDI POWDER FOR ORAL SOLUTION 0.75 MG/MLIsometheptene
go.drugbank.com/drugs/DB06706ApprovedIsometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches.
Mixtures: DIPIRONA 300 MG + ISOMETEPTENO MUCATO 30 MG + CAFEINA 30 MG, DIPIRONA 300 MG + ISOMETEPTENO 50 MG + CAFEINA 30 MG GOTASPivmecillinam
go.drugbank.com/drugs/DB01605ApprovedInvestigationalPivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa.
Categories: combinations of penicillinsProducts: Selexid 200 mg Filmtabletten, Selexid 400 mg film-coated tablets