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Displaying results 1611 - 1620 of 10000 in total
  1. Drug

    Pergolide

    go.drugbank.com/drugs/DB01186
    ApprovedVet approvedWithdrawn

    The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007. … It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Adrenergic alpha-1 Receptor Agonists
  2. Drug

    Manganese gluconate

    go.drugbank.com/drugs/DB11141
    Approved

    It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. … Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O.

    Mixtures: Vital Be-100, E 400iu W Selenium 100mcg
  3. Drug

    Valsartan

    go.drugbank.com/drugs/DB00177
    ApprovedInvestigational

    Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [olmesartan], and [irbesartan]. … ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis

    Mixtures: AMLODIPINA E VALSARTAN DOC, AMLODIPINA E VALSARTAN DOCCategories: Agents Acting on the Renin-Angiotensin System, Angiotensin 2 Receptor Blocker
  4. Drug

    Quinapril

    go.drugbank.com/drugs/DB00881
    ApprovedInvestigational

    Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure. … [L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.

    Mixtures: QUINAPRIL E IDROCLOROTIAZIDE ACTAVIS, QUINAPRIL E IDROCLOROTIAZIDE MYLAN GENERICSCategories: Agents Acting on the Renin-Angiotensin System
  5. Drug

    Fenproporex

    go.drugbank.com/drugs/DB01550
    ApprovedIllicitWithdrawn

    The N-2-cyanoethyl substituent was once believed to be resistant to cleavage, because fenproporex -- once recommended as an obesity treatment for patients with cardiovascular disease -- was originally … Contrary to the claim, research has demonstrated easy in vivo cleavage of the N-2-cyanothyl substituent to yield amphetamine as a metabolite. [5] However, in clinical practice, central nervous system stimulative

  6. Drug

    Ethynodiol diacetate

    go.drugbank.com/drugs/DB00823
    Approved

    Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug

    Categories: Sex Hormones and Modulators of the Genital System
  7. Drug

    Novobiocin

    go.drugbank.com/drugs/DB01051
    ApprovedInvestigationalVet approvedWithdrawn

    It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. … infections due to susceptible strains of _Staphylococcus aureus_ when other less toxic antibiotics cannot be used.

  8. Drug

    Thalidomide

    go.drugbank.com/drugs/DB01041
    ApprovedInvestigationalWithdrawn

    Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception … A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects.

  9. Drug

    Tegaserod

    go.drugbank.com/drugs/DB01079
    ApprovedWithdrawn

    in female patients less than 65 years of age and whom are considered to be at a lower risk of a cardiovascular event than the broader population. … natural secretions in the gut, among others.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin-4 Receptor Agonist
  10. Drug

    Phentermine

    go.drugbank.com/drugs/DB00191
    ApprovedIllicitInvestigational

    [A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). … [A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: TERFAMEX T