Fenproporex is an orally active stimulant drug, which was developed in the 1960s. It is used as an appetite suppressant and a treatment for obesity. It is listed as an... It is listed as an illicit substance in many countries due to addiction issues and listed as a prohibited substance by the World Anti-Doping Agency.
- Mechanism
- Curator reviewed
Fenproporex is an amphetamine based anorectic which is rapidly metabolized into amphetamine in the body. Both acute and chronic fenproporex administration has been shown to increase brain energy metabolism in young rats, by increasing the activity of citrate synthase, malate dehydrogenase, succinate dehydrogenase, creatine kinase and complexes I,II, III, and IV.
Amphetamine based drugs are also known to reduce food intake. They are addictive substances due to their ability to increase dopamine release, however their anorectic effects are believed to be a result of noradrenergic neurotransmission. Activation of the alpha 1 and beta 2 adrenoceptors has been shown to decrease food intake, and drugs which release norepinephrine or block norepinephrine reuptake can activate these receptors.
The alpha 1 and beta 2 adrenoceptors are noted to be clinically important receptors in weight regulation.
- Primary indication
- Fenproporex is used as an appetite suppressant, and anti-obesity agent; however, due to substance abuse potential, it is an illicit substance in many countries.Curator reviewed
- Formula / weight
- C12H16N2 · 188.2688 g/mol (avg)
Resolves to
IQUFSXIQAFPIMR-UHFFFAOYSA-NSMILESCC(CC1=CC=CC=C1)NCCC#NWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Fenproporex, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account