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Colistin
go.drugbank.com/drugs/DB00803ApprovedInvestigationalIt is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. … Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Mixtures: Coly-Mycin S, Coly-Mycin SCategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexLeuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigationalProlonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced … Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three
International brands: Prostap 3Products: LUCRIN DEPOT-3 M 11,25 IM/SC ENJEKSIYONLUK FLAKON, 1 ADET, LUCRIN DEPOT-3,75 MG IM/SC ENJEKSIYONLUK FLAKON, 1 ADETKeratoconjunctivitis Sicca (KCS)
go.drugbank.com/conditions/DBCOND0105777Drugs: Hydroxypropyl celluloseSynonyms: Keratoconjunctivitis sicca, in Sjögren syndrome, Keratoconjunctivitis sicca, in Sjogren's syndromeMirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigational[L32853] An extended-release granule formulation was subsequently granted approval in March 2021 for the treatment of pediatric patients with neurogenic detrusor overactivity. … Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: MYRBETRIC® 50 MG TABLETAS DE LIBERACION PROLONGADA, MYRBETRIC® 25 MG TABLETAS DE LIBERACION PROLONGADAMometasone furoate
go.drugbank.com/drugs/DB14512ApprovedInvestigationalVet approvedMometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. … Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different indications[FDA Label][F4292,F4295].
Mixtures: M-FURO FA %0.1 + %2 KREM, 30 G, DERMOTIL-S® UNGUENTOCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersCentral Diabetes Insipidus
go.drugbank.com/conditions/DBCOND0051168Drugs: DesmopressinSynonyms: DI - Diabetes insipidusPrednisolone
go.drugbank.com/drugs/DB00860ApprovedInvestigationalVet approved[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431] … Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.
Synonyms: Predniso(lo)ne, delta(1)-HydrocortisoneInternational brands: Di-Adreson F, Di-Adreson-FCyclosporine
go.drugbank.com/drugs/DB00091ApprovedInvestigationalVet approved[A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118] … Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: Cyclosporin A, Cyclosporine AAlemtuzumab
go.drugbank.com/drugs/DB00087ApprovedInvestigationalAlemtuzumab is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.[L43397] Alemtuzumab was approved by the FDA in 2001. … Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens.
Synonyms: Campath 1-HProducts: MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP), LEMTRADA®Diabetic enteropathy
go.drugbank.com/conditions/DBCOND0009307Drugs: ClonidineSynonyms: Diarrhea in diabetes, Diarrhoea in diabetes