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Orlistat
go.drugbank.com/drugs/DB01083ApprovedInvestigationalIn some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical intervention is required. … Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare.
Pergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnPergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors...
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: PERGOLIDE MYLAN GENERICSTavaborole
go.drugbank.com/drugs/DB09041ApprovedTavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes … Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu).
Dinoprostone
go.drugbank.com/drugs/DB00917ApprovedInvestigationalAs a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour. … It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.
Belzutifan
go.drugbank.com/drugs/DB15463ApprovedInvestigational[L36105] Initially considered to be undruggable, a binding pocket was eventually discovered in the HIF-2α molecule which allowed for compounds to bind and inhibit these proteins. … This discovery led to the initial development of belzutifan (at the time called PT2977), which was further developed by a spin-off company named Peloton Pharmaceuticals (which itself was eventually acquired
Quinidine barbiturate
go.drugbank.com/drugs/DB01346ApprovedThe administration of quinidine derivatives helps to observe various skin and mucosal reactions. … A papulopurpuric eruption in a patient (without thrombopenia) can be developed who is taking quinidine phenylethyl barbiturate intermittently and at reintroduction.(PMID: 9739909)
Testosterone cypionate
go.drugbank.com/drugs/DB13943ApprovedInvestigationalIts benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life.
Remifentanil
go.drugbank.com/drugs/DB00899ApprovedInvestigationalRemifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: REMIFENTANILO 2MG POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE O INFUSION INTRAVENOSA, REMIFENTANIL MYLAN GENERICSBarium sulfate
go.drugbank.com/drugs/DB11150ApprovedIt is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield [L1957]. This drug is used as a contrast agent in diagnostic x-ray procedures. … Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization
Products: Liqui-coat Hd - Sus Orl 210%w/v 81%w/w, Medebar Plus - Sus Orl RT 56%w/w 100%w/vOlaratumab
go.drugbank.com/drugs/DB06043ApprovedInvestigationalIt is composed of two heavy chain molecule fragments and 2 light chain fragments. … Olaratumab was granted accelerated approval (as Lartruvo) as initial therapy to treat adults with certain types of soft tissue sarcoma (STS) in October, 2016.