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Colestipol
go.drugbank.com/drugs/DB00375Approved, patients who take complicated medication regimens, experience constipation or biliary obstruction, etc. may not be good candidates for using the agent owing to its physical effects on the gut. … [FDA Label, F4555, F4567, L6262] Alternatively, colestipol predominantly elicits its activities within the gut environment because it undergoes little absorption and metabolism.
Categories: Compounds used in a research, industrial, or household settingLumateperone
go.drugbank.com/drugs/DB06077ApprovedInvestigational[A189093] It has a unique receptor binding profile and differs from other antipsychotics in that it modulates glutamate, serotonin and dopamine, which are all neurotransmitters that contribute to the pathophysiology … [A189093] Further, not only is the new antipsychotic selective for dopamine (D2) receptors in the mesolimbic and mesocortical brain regions, but it also has minimal off-target activity.
Telotristat ethyl
go.drugbank.com/drugs/DB12095Approved[A252937] The first line treatment of carcinoid syndrome diarrhea is SSA, but symptoms still reoccur over the course of the disease.[A252937] … [A252937] Serotonin is metabolized in the urinary metabolite 5-hydroxy indole acetic acid (u5-HIAA), and high levels of u5-HIAA is associated with poor survival outcome in patients with NET.
Abiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalIt is used to treat metastatic castration-resistant prostate cancer, hormone-sensitive high-risk metastatic prostate cancer. … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Products: ABIRAND® 500 MG, BIRANONA ® 250 MGSarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigational, fungal overgrowth, etc. … Subsequently, while a number of first line tetracycline therapies like doxycycline and minocycline do exist for treating acne vulgaris, sarecycline presents a new and innovative therapy choice because
Segesterone acetate
go.drugbank.com/drugs/DB14583ApprovedIt is commonly sold under the brand names Nestorone and Elcometrine and serves as an active component in hormonal contraceptives. … Segesterone acetate is not an orally active compound, but it is proved to be a potent anti-ovulatory agent when given in implants, vaginal rings or percutaneous gel [A37090].
Synonyms: 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetateLimaprost
go.drugbank.com/drugs/DB09211InvestigationalLimaprost (as Limaprost alfadex; CAS number 88852-12-4) is an oral prostaglandin E1 analog. … It also improves poor blood flow in the nerve tissue in cervical spondylosis and normalizes nerve function.
Categories: Prostaglandins ELepirudin
go.drugbank.com/drugs/DB00001ApprovedWithdrawnat position 1 (N-terminal end). … [L41539] Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine
Chlormadinone acetate
go.drugbank.com/drugs/DB15903ApprovedWithdrawnHowever, the use of these drugs was associated with the development of mammary tumors in dogs. In 1972, the FDA withdrew its approval for the use of chlormadinone acetate in all products. … Chlormadinone acetate is a progesterone derivative first synthesized in 1961.
Mixtures: BELARA film-coated tablet 0.03mg/2mg, LUTORAL-EGadoteridol
go.drugbank.com/drugs/DB00597ApprovedInvestigationalgadolinium in the brain. … [A263076] Initially approved by the FDA in 1992, gadoteridol received additional approval in 2020 for use in pediatric patients less than 2 years old.[L49876]
Categories: Compounds used in a research, industrial, or household settingProducts: ProHance 279.3 mg/ml solution for injection