DB09211InvestigationalSmall molecule
Limaprost is an oral prostaglandin E1 analogue used to improve symptoms associated with thromboangiitis obliterans, acquired lumbar spinal canal stenosis, and other ischemic conditions. Limaprost (as Limaprost alfadex; CAS number 88852-12-4) is an oral prostaglandin E1 analog.
- Mechanism
- Curator reviewed · 1 reference
As a prostglandin E1 analog, limaprost acts as an agonist at prostraglandin E2 receptors. It likely stimulates the adenylate cyclase coupled E2 subtype of these receptors to produce smooth muscle relaxation.
- Primary indication
- Limaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain and numbness of lower legs)...Curator reviewed · 3 structured indications
- Formula / weight
- C22H36O5 · 380.525 g/mol (avg)
- Also known as
- Limaprost alfadex
Resolves to
Clinical / RWD
Structure
InChIKey
OJZYRQPMEIEQFC-UAWLTFRCSA-NSMILESCCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=OWhat you can answer from here — as of May 07, 2021
4Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Limaprost, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account