Chlormadinone acetate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Chlormadinone acetate is a progestin indicated in combination with an estrogen for birth control.

Generic Name
Chlormadinone acetate
DrugBank Accession Number
DB15903
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 404.93
Monoisotopic: 404.1754371
Chemical Formula
C23H29ClO4
Synonyms
  • Chlormadinone acetate

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Chlormadinone acetate is combined with Abciximab.
AcenocoumarolThe risk or severity of adverse effects can be increased when Chlormadinone acetate is combined with Acenocoumarol.
AcetaminophenThe metabolism of Chlormadinone acetate can be increased when combined with Acetaminophen.
AcetazolamideThe metabolism of Chlormadinone acetate can be increased when combined with Acetazolamide.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Chlormadinone acetate.
AlpelisibThe metabolism of Chlormadinone acetate can be increased when combined with Alpelisib.
AlteplaseThe risk or severity of adverse effects can be increased when Chlormadinone acetate is combined with Alteplase.
AminoglutethimideThe metabolism of Chlormadinone acetate can be increased when combined with Aminoglutethimide.
AmobarbitalThe metabolism of Chlormadinone acetate can be increased when combined with Amobarbital.
AmoxicillinThe therapeutic efficacy of Chlormadinone acetate can be decreased when used in combination with Amoxicillin.
Interactions
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Food Interactions
Not Available

Products

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Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
0SY050L61N
CAS number
302-22-7
InChI Key
QMBJSIBWORFWQT-DFXBJWIESA-N
InChI
InChI=1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1
IUPAC Name
(1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-5-chloro-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
SMILES
[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(Cl)C2=CC(=O)CC[C@]12C

References

General References
  1. AIFA: Belara (Chlormadinone Acetate, Ethinylestradiol) Oral Tablet [Link]
KEGG Compound
C12729
ChemSpider
8963
RxNav
2369
ChEBI
31394
ChEMBL
CHEMBL110691
ZINC
ZINC000003876041
Wikipedia
Chlormadinone_acetate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Unknown StatusNot AvailablePharmacogenomics / Systems Biology1
4Unknown StatusTreatmentWeight Changes1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, film coatedOral
Tablet, film coatedOral2 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00158 mg/mLALOGPS
logP3.58ALOGPS
logP3.72ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)17.83ChemAxon
pKa (Strongest Basic)-5.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area60.44 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity109.09 m3·mol-1ChemAxon
Polarizability43.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 19, 2020 23:02 / Updated on May 07, 2021 21:08