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Displaying results 1671 - 1680 of 7181 in total
  1. Drug

    Benserazide

    go.drugbank.com/drugs/DB12783
    ApprovedInvestigational

    of dopamine from levadopa in extracerebral tissues - thereby acting to minimize the occurrence of extracerebral side effects [F2, L2553]. … A decarboxylase inhibitor like benserazide is consequently an effective compound to combine with levadopa as it is incapable of crossing the blood-brain barrier itself but acts to prevent the formation

    Mixtures: MADOPAR 125 T, MADOPAR 125 T
  2. Drug

    Olmesartan

    go.drugbank.com/drugs/DB00275
    ApprovedInvestigational

    ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis … ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.

    Mixtures: OPENVAS CO, ALMETEC-CO
  3. Drug

    Debrisoquine

    go.drugbank.com/drugs/DB04840
    Approved

    They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. … Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs.

  4. Drug

    Cysteamine

    go.drugbank.com/drugs/DB00847
    ApprovedInvestigational

    Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.[L15601] … [A218721] Several preparations of cysteamine exist for the treatment of cystinosis manifestations, some in capsule form, and others in ophthalmic solution form.

  5. Drug

    Isoprenaline

    go.drugbank.com/drugs/DB01064
    ApprovedInvestigational

    [A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. … Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion

    Synonyms: N-Isopropylnoradrenaline, N-Isopropylnorepinephrine
  6. Drug

    Propoxycaine

    go.drugbank.com/drugs/DB09342
    Approved

    Although no longer available in the United States, this medication was used in combination with procaine to aid in anesthesia during dental procedures [L1592]. … This drug was removed from the US market in 1996.

  7. Drug

    Tiludronic acid

    go.drugbank.com/drugs/DB01133
    ApprovedVet approvedWithdrawn

    [A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. … Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].

  8. Drug

    Rubidium Rb-82

    go.drugbank.com/drugs/DB09479
    ApprovedInvestigational

    It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected

  9. Drug

    Levofloxacin

    go.drugbank.com/drugs/DB01137
    ApprovedInvestigational

    (i.e. it does not invert to the inactive isomer). … [A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin[A190663] and remains stereochemically stable following administration

    Synonyms: Ofloxacin S-(-)-form
  10. Drug

    Ecallantide

    go.drugbank.com/drugs/DB05311
    Approved

    Apart from its FDA and EMA indication, ecallantide has been used off label in the management of nonhistaminergic angioedema, not due to HAE [A32017]. … The amino acid sequence of two compounds differ by seven amino acids [L1458].